Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer
Objective: to study the radiological and sonographic features of microcarcinomas of various biological subtypes.Materials and methods. The analysis included 59 patients (median age – 55 years) with invasive breast cancer (BC) pT1a–bN0M0 stages at the N.N. Blokhin Russian Cancer Research Center. The...
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doaj-b5b47eb0332a446f9ea13228464652562021-07-29T08:46:53ZrusABV-pressOpuholi Ženskoj Reproduktivnoj Sistemy1994-40981999-86272021-03-01164213410.17650/1994-4098-2020-16-4-12-34662Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancerG. S. Alieva0G. P. Korzhenkova1I. V. Kolyadina2N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaN.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaRussian Medical Academy of Postgraduate Education, Ministry of Health of RussiaObjective: to study the radiological and sonographic features of microcarcinomas of various biological subtypes.Materials and methods. The analysis included 59 patients (median age – 55 years) with invasive breast cancer (BC) pT1a–bN0M0 stages at the N.N. Blokhin Russian Cancer Research Center. The frequency of distribution of luminal A, luminal B HER2 negative, HER2 positive (HER2+) and triple negative subtypes of BC was 39 %, 23.7 %, 23.7 % and 6.8 %, respectively. The analysis of key radiological characteristics and sonographic features of microcarcinomas with different biological structures associated with the diagnosis according to the BI-RADS criteria was carried out.Results. Tumors with luminal A and B subtypes had the most characteristic of malignancy (presence of a node ± microcalcinates), which allowed us to establish the category of BI-RADS 4–5 in mammography (MMG) in 82 % and 88.9 % of patients, respectively. Triple negative cancer is characterized by the presence of a node without microcalcifications; the BI-RADS 4–5 category is exposed in 75 % of cases. Maximum of the difficulties noted in the diagnosis of HER2+ subtype: 4 type density BC (18.2 % of cases), absence of tumor site during surgery in 57.1 % of cases and atypical characteristics of the node (16.7 %) and iso/hypodense structure node (33.4 %) resulted in high frequency of false-negative results in MMG (BI-RADS 0–3 35.7 %), p = 0.049. In addition, HER2+ early BC has proven to be the most difficult subtype for sonographic diagnosis too. The absence of a tumor node in sonography in 14.2 % of cases, as well as its atypical characteristics (iso/hyper echogenicity in 16.7 % of cases and the absence of an acoustic shadow in 18.2 % of patients) led to a high frequency of BI-RADS 0 (21.4 %), which required further examination of these patients. Conclusions. HER2+ early BC was the most difficult biological subtype for MMG and sonographic diagnosticshttps://ojrs.abvpress.ru/ojrs/article/view/774early breast cancermicrocarcinomas of various biological subtypescategories of bi-radsbreast calcificationsmammographic and sonographic signs of malignancy |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
G. S. Alieva G. P. Korzhenkova I. V. Kolyadina |
spellingShingle |
G. S. Alieva G. P. Korzhenkova I. V. Kolyadina Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer Opuholi Ženskoj Reproduktivnoj Sistemy early breast cancer microcarcinomas of various biological subtypes categories of bi-rads breast calcifications mammographic and sonographic signs of malignancy |
author_facet |
G. S. Alieva G. P. Korzhenkova I. V. Kolyadina |
author_sort |
G. S. Alieva |
title |
Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer |
title_short |
Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer |
title_full |
Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer |
title_fullStr |
Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer |
title_full_unstemmed |
Possibilities of mammography, ultrasound, and MRI in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer |
title_sort |
possibilities of mammography, ultrasound, and mri in the differential diagnosis of microcarcinomas of various biological subtypes of invasive breast cancer |
publisher |
ABV-press |
series |
Opuholi Ženskoj Reproduktivnoj Sistemy |
issn |
1994-4098 1999-8627 |
publishDate |
2021-03-01 |
description |
Objective: to study the radiological and sonographic features of microcarcinomas of various biological subtypes.Materials and methods. The analysis included 59 patients (median age – 55 years) with invasive breast cancer (BC) pT1a–bN0M0 stages at the N.N. Blokhin Russian Cancer Research Center. The frequency of distribution of luminal A, luminal B HER2 negative, HER2 positive (HER2+) and triple negative subtypes of BC was 39 %, 23.7 %, 23.7 % and 6.8 %, respectively. The analysis of key radiological characteristics and sonographic features of microcarcinomas with different biological structures associated with the diagnosis according to the BI-RADS criteria was carried out.Results. Tumors with luminal A and B subtypes had the most characteristic of malignancy (presence of a node ± microcalcinates), which allowed us to establish the category of BI-RADS 4–5 in mammography (MMG) in 82 % and 88.9 % of patients, respectively. Triple negative cancer is characterized by the presence of a node without microcalcifications; the BI-RADS 4–5 category is exposed in 75 % of cases. Maximum of the difficulties noted in the diagnosis of HER2+ subtype: 4 type density BC (18.2 % of cases), absence of tumor site during surgery in 57.1 % of cases and atypical characteristics of the node (16.7 %) and iso/hypodense structure node (33.4 %) resulted in high frequency of false-negative results in MMG (BI-RADS 0–3 35.7 %), p = 0.049. In addition, HER2+ early BC has proven to be the most difficult subtype for sonographic diagnosis too. The absence of a tumor node in sonography in 14.2 % of cases, as well as its atypical characteristics (iso/hyper echogenicity in 16.7 % of cases and the absence of an acoustic shadow in 18.2 % of patients) led to a high frequency of BI-RADS 0 (21.4 %), which required further examination of these patients. Conclusions. HER2+ early BC was the most difficult biological subtype for MMG and sonographic diagnostics |
topic |
early breast cancer microcarcinomas of various biological subtypes categories of bi-rads breast calcifications mammographic and sonographic signs of malignancy |
url |
https://ojrs.abvpress.ru/ojrs/article/view/774 |
work_keys_str_mv |
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