Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer
Abstract Background This study aimed to investigate the efficacy and safety of cytokine-induced killer (CIK)/dendritic cell combined with CIK (DC–CIK) cell therapy in advanced gastrointestinal cancer (GIC). Methods The PubMed, Cochrane library, and Embase were searched to conduct a meta-analysis of...
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doaj-b5d0820f6072482ebe1122e39bd696782020-11-25T02:19:14ZengBMCBMC Cancer1471-24072020-04-0120111110.1186/s12885-020-06860-yCytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancerHansong Du0Jia Yang1Ying Zhang2Department of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biochemistry & Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background This study aimed to investigate the efficacy and safety of cytokine-induced killer (CIK)/dendritic cell combined with CIK (DC–CIK) cell therapy in advanced gastrointestinal cancer (GIC). Methods The PubMed, Cochrane library, and Embase were searched to conduct a meta-analysis of clinical controlled trials to evaluate the efficacy and safety of CIK/DC–CIK cell therapy in advanced GIC. The pooled risk ratios (RRs) or weighted mean difference (WMD) with 95% confidence intervals (95% CIs) were calculated. Results A total of nine studies with 1113 patients were identified. The overall survival (RR = 1.84, 95% CI = 1.41–2.40, P heterogeneity = 0.654, I 2 = 0%), progression-free survival (RR = 1.99, 95% CI = 1.52–2.60, P heterogeneity = 0.727, I 2 = 0%), and quality of life (WMD = 16.09, 95% CI = 1.66–30.52, P heterogeneity < 0.001, I 2 = 98.8%) were significantly improved in patients who received chemotherapy combined with CIK/DC–CIK cells, and no severe adverse events were reported. Conclusion This meta-analysis suggested that the combination of CIK/DC–CIK immunotherapy and chemotherapy was safe and applicable for patients with advanced GIC. It is a feasible choice to prolong survival and improve quality of life.http://link.springer.com/article/10.1186/s12885-020-06860-yAdvanced gastrointestinal cancerCytokine-induced killerDendritic cellMeta-analysisSystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hansong Du Jia Yang Ying Zhang |
spellingShingle |
Hansong Du Jia Yang Ying Zhang Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer BMC Cancer Advanced gastrointestinal cancer Cytokine-induced killer Dendritic cell Meta-analysis Systematic review |
author_facet |
Hansong Du Jia Yang Ying Zhang |
author_sort |
Hansong Du |
title |
Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer |
title_short |
Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer |
title_full |
Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer |
title_fullStr |
Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer |
title_full_unstemmed |
Cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer |
title_sort |
cytokine-induced killer cell/dendritic cell combined with cytokine-induced killer cell immunotherapy for treating advanced gastrointestinal cancer |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2020-04-01 |
description |
Abstract Background This study aimed to investigate the efficacy and safety of cytokine-induced killer (CIK)/dendritic cell combined with CIK (DC–CIK) cell therapy in advanced gastrointestinal cancer (GIC). Methods The PubMed, Cochrane library, and Embase were searched to conduct a meta-analysis of clinical controlled trials to evaluate the efficacy and safety of CIK/DC–CIK cell therapy in advanced GIC. The pooled risk ratios (RRs) or weighted mean difference (WMD) with 95% confidence intervals (95% CIs) were calculated. Results A total of nine studies with 1113 patients were identified. The overall survival (RR = 1.84, 95% CI = 1.41–2.40, P heterogeneity = 0.654, I 2 = 0%), progression-free survival (RR = 1.99, 95% CI = 1.52–2.60, P heterogeneity = 0.727, I 2 = 0%), and quality of life (WMD = 16.09, 95% CI = 1.66–30.52, P heterogeneity < 0.001, I 2 = 98.8%) were significantly improved in patients who received chemotherapy combined with CIK/DC–CIK cells, and no severe adverse events were reported. Conclusion This meta-analysis suggested that the combination of CIK/DC–CIK immunotherapy and chemotherapy was safe and applicable for patients with advanced GIC. It is a feasible choice to prolong survival and improve quality of life. |
topic |
Advanced gastrointestinal cancer Cytokine-induced killer Dendritic cell Meta-analysis Systematic review |
url |
http://link.springer.com/article/10.1186/s12885-020-06860-y |
work_keys_str_mv |
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