Renal Involvement in Multiple Myeloma

• Main Authors: Joana Gameiro, Sofia Jorge, José António Lopes
• Format: Article
• Language: English
• Published: European Medical Journal 2017-08-01
• Series: European Medical Journal
• Subjects: multiple myeloma (mm); renal impairment (ri); pathogenesis; treatment
• Online Access: https://www.emjreviews.com/oncology/article/editors-pick-renal-involvement-in-multiple-myeloma/

Multiple myeloma (MM) is a plasma cell disorder that represents almost 10% of haematologic malignancies. Renal impairment, one of the most common complications of MM that occurs in 20–50% of patients, can present in a variety of forms and is associated with increased mortality. Myeloma cast nephropathy is the most common cause of kidney disease in MM patients, presenting as acute kidney injury in the majority of patients. The recent introduction of new chemotherapy agents, autologous stem cell transplantation, and the development of novel techniques of light chain removal have been associated with improved renal and patient outcomes in MM patients. Nevertheless, dialysis-dependent patients with MM have higher mortality than other dialysis patients and may be considered for kidney transplantation only if sustained remission has been achieved and sustained for at least 3 years, bearing in mind the risk of disease recurrence. The authors review the most frequent renal manifestations associated with MM, namely myeloma cast nephropathy, light-chain amyloidosis, and monoclonal immunoglobulin deposition disease, focussing on the therapeutic options for acute and chronic kidney disease.