Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children

Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children

Abstract Background Age-related changes in adaptive and innate immune cells have been associated with a decline in effective immunity and chronic, low-grade inflammation. Epigenetic, transcriptional, and functional changes in monocytes occur with aging, though most studies to date have focused on di...

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Bibliographic Details
Main Authors: Katherine R. Dobbs, Paula Embury, Emmily Koech, Sidney Ogolla, Stephen Munga, James W. Kazura, Arlene E. Dent
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Immunity & Ageing
Subjects:
Monocyte
DNA methylation
Epigenetic
Ageing
Aging
Innate immune
Online Access:https://doi.org/10.1186/s12979-021-00223-2

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