Facial nerve repair utilizing intraoperative repair strategies
Abstract Objectives To determine whether functional and anatomical outcomes following suture neurorrhaphy are improved by the addition of electrical stimulation with or without the addition of polyethylene glycol (PEG). Methods In a rat model of facial nerve injury, complete facial nerve transection...
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Series: | Laryngoscope Investigative Otolaryngology |
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Online Access: | https://doi.org/10.1002/lio2.411 |
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doaj-b5dfdacb51d74d17935641292c38422e2020-11-25T02:47:52ZengWileyLaryngoscope Investigative Otolaryngology2378-80382020-06-015355255910.1002/lio2.411Facial nerve repair utilizing intraoperative repair strategiesBrandon L. Brown0Morgan M. Sandelski1Sarah M. Drejet2Elizabeth M. Runge3Taha Z. Shipchandler4Kathryn J. Jones5Chandler L. Walker6Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USADepartment of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USADepartment of Otolaryngology Indiana University School of Medicine Indianapolis Indiana USADepartment of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USADepartment of Otolaryngology Indiana University School of Medicine Indianapolis Indiana USADepartment of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USADepartment of Anatomy, Cell Biology and Physiology Indiana University School of Medicine Indianapolis Indiana USAAbstract Objectives To determine whether functional and anatomical outcomes following suture neurorrhaphy are improved by the addition of electrical stimulation with or without the addition of polyethylene glycol (PEG). Methods In a rat model of facial nerve injury, complete facial nerve transection and repair was performed via (a) suture neurorrhaphy alone, (b) neurorrhaphy with the addition of brief (30 minutes) intraoperative electrical stimulation, or (c) neurorrhaphy with the addition electrical stimulation and PEG. Functional recovery was assessed weekly for 16 weeks. At 16 weeks postoperatively, motoneuron survival, amount of regrowth, and specificity of regrowth were assessed by branch labeling and tissue analysis. Results The addition of brief intraoperative electrical stimulation improved all functional outcomes compared to suturing alone. The addition of PEG to electrical stimulation impaired this benefit. Motoneuron survival, amount of regrowth, and specificity of regrowth were unaltered at 16 weeks postoperative in all treatment groups. Conclusion The addition of brief intraoperative electrical stimulation to neurorrhaphy in this rodent model shows promising neurological benefit in the surgical repair of facial nerve injury. Level of Evidence Animal study.https://doi.org/10.1002/lio2.411electrical stimulationfacial nervefacial nerve injurynerve repairpolyethylene glycol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brandon L. Brown Morgan M. Sandelski Sarah M. Drejet Elizabeth M. Runge Taha Z. Shipchandler Kathryn J. Jones Chandler L. Walker |
spellingShingle |
Brandon L. Brown Morgan M. Sandelski Sarah M. Drejet Elizabeth M. Runge Taha Z. Shipchandler Kathryn J. Jones Chandler L. Walker Facial nerve repair utilizing intraoperative repair strategies Laryngoscope Investigative Otolaryngology electrical stimulation facial nerve facial nerve injury nerve repair polyethylene glycol |
author_facet |
Brandon L. Brown Morgan M. Sandelski Sarah M. Drejet Elizabeth M. Runge Taha Z. Shipchandler Kathryn J. Jones Chandler L. Walker |
author_sort |
Brandon L. Brown |
title |
Facial nerve repair utilizing intraoperative repair strategies |
title_short |
Facial nerve repair utilizing intraoperative repair strategies |
title_full |
Facial nerve repair utilizing intraoperative repair strategies |
title_fullStr |
Facial nerve repair utilizing intraoperative repair strategies |
title_full_unstemmed |
Facial nerve repair utilizing intraoperative repair strategies |
title_sort |
facial nerve repair utilizing intraoperative repair strategies |
publisher |
Wiley |
series |
Laryngoscope Investigative Otolaryngology |
issn |
2378-8038 |
publishDate |
2020-06-01 |
description |
Abstract Objectives To determine whether functional and anatomical outcomes following suture neurorrhaphy are improved by the addition of electrical stimulation with or without the addition of polyethylene glycol (PEG). Methods In a rat model of facial nerve injury, complete facial nerve transection and repair was performed via (a) suture neurorrhaphy alone, (b) neurorrhaphy with the addition of brief (30 minutes) intraoperative electrical stimulation, or (c) neurorrhaphy with the addition electrical stimulation and PEG. Functional recovery was assessed weekly for 16 weeks. At 16 weeks postoperatively, motoneuron survival, amount of regrowth, and specificity of regrowth were assessed by branch labeling and tissue analysis. Results The addition of brief intraoperative electrical stimulation improved all functional outcomes compared to suturing alone. The addition of PEG to electrical stimulation impaired this benefit. Motoneuron survival, amount of regrowth, and specificity of regrowth were unaltered at 16 weeks postoperative in all treatment groups. Conclusion The addition of brief intraoperative electrical stimulation to neurorrhaphy in this rodent model shows promising neurological benefit in the surgical repair of facial nerve injury. Level of Evidence Animal study. |
topic |
electrical stimulation facial nerve facial nerve injury nerve repair polyethylene glycol |
url |
https://doi.org/10.1002/lio2.411 |
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