| Summary: | Objective: To study the effect of hemodialysis (HD) combined with hemoperfusion (HP) on
dialysis efficiency, lipid metabolism and atherosclerosis in patients with uremia. Methods:
A total of 70 patients with uremia who were treated in our hospital between March 2013
and October 2015 were collected and divided into observation group and control group
(n=35) according to double-blind randomized control method. Observation group of patients
received hemodialysis combined with hemoperfusion, control group of patients received
hemodialysis alone, and the treatment lasted for 6 months. After 6 months of intervention,
automatic biochemical analyzer was used to detect renal function indexes and lipid metabolism
indexes, and the two-dimensional ultrasound was used to quantitatively determine the carotid
atherosclerosis parameters. Results: Before intervention, differences in renal function, lipid
metabolism and atherosclerosis levels were not statistically significant between two groups
of patients; after 6 months of intervention, renal function indexes blood urea nitrogen (BUN),
serum creatinine (Scr), β2-microglobulin (β2-MG) and blood uric acid (BUA) levels of
observation group were lower than those of control group, lipid metabolism indexes total
cholesterol (TC), triglyceride (TG), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB)
levels were lower than those of control group, and differences between groups were statistically
significant; quantitative carotid ultrasound parameters gray-scale median (GSM) of observation
group was higher than that of control group, enhanced intensity (EI) and enhanced density
(ED) were lower than those of control group, and differences between groups were statistically
significant. Conclusion: Hemodialysis combined with hemoperfusion can improve the dialysis
efficiency, also reduce lipid metabolism disturbance and delay the formation of atherosclerosis
in patients with uremia.
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