Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Abstract Background Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating disease process. Radiotherapy is an essential method to treat NPC. In th...

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Bibliographic Details
Main Authors: Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
PAD4
GSK484
Radiosensitivity
Nasopharyngeal carcinoma
Online Access:https://doi.org/10.1186/s11658-021-00251-2

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