Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review)
This article provides the review of the medical use of pH- and temperature-sensitive polymer hydrogels. Such polymers are characterised by their thermal and pH sensitivity in aqueous solutions at the functioning temperature of living organisms and can react to the slightest changes in environmental...
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Voronezh State University
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doaj-b5e8d196ee924d9eaa80de0508a22e1b2020-12-28T06:19:32ZengVoronezh State UniversityКонденсированные среды и межфазные границы1606-867X1606-867X2020-12-0122410.17308/kcmf.2020.22/3113Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review)Vyacheslav A. Kuznetsov0https://orcid.org/0000-0002-5508-6978National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov of the Ministry of Healthcare of the Russian Federation, ul. Academika Oparina 4, Moscow, 117997, Russian Federation; Voronezh State University, 1 Universitetskaya pl., Voronezh, 394018, Russian Federation DSc in Chemistry, Professor of the Department of Chemistry of High- Molecular Compounds and Colloid Chemistry, Voronezh State University, Voronezh, Russian Federation, Senior Researcher at the clinical immunology laboratory of the National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after V. I. Kulakov of the Ministry of Healthcare of the Russian Federation, Moscow, Russian FederationThis article provides the review of the medical use of pH- and temperature-sensitive polymer hydrogels. Such polymers are characterised by their thermal and pH sensitivity in aqueous solutions at the functioning temperature of living organisms and can react to the slightest changes in environmental conditions. Due to these properties, they are called stimuli-sensitive polymers. This response to an external stimulus occurs due to the amphiphilicity (diphilicity) of these (co)polymers. The term hydrogels includes several concepts of macrogels and microgels. Microgels, unlike macrogels, are polymer particles dispersed in a liquid and are nano- or micro-objects. The review presents studies reflecting the main methods of obtaining such polymeric materials, including precipitation polymerisation, as the main, simplest, and most accessible method for mini-emulsion polymerisation, microfluidics, and layer-by-layer adsorption of polyelectrolytes. Such systems will undoubtedly be promising for use in biotechnology and medicine due to the fact that they are liquid-swollen particles capable of binding and carrying various low to high molecular weight substances. It is also important that slight heating and cooling or a slight change in the pH of the medium shifts the system from a homogeneous to a heterogeneous state and vice versa. This provides the opportunity to use these polymers as a means of targeted drug delivery, thereby reducing the negative effect of toxic substances used for treatment on the entire body and directing the action to a specific point. In addition, such polymers can be used to create smart coatings of implanted materials, as well as an artificial matrix for cell and tissue regeneration, contributing to a significant increase in the survival rate and regeneration rate of cells and tissues.https://journals.vsu.ru/kcmf/article/view/3113hydrogelmicrogeln-isopropylacrylamidethermal sensitivityph sensitivityheterophase polymerisation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vyacheslav A. Kuznetsov |
spellingShingle |
Vyacheslav A. Kuznetsov Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review) Конденсированные среды и межфазные границы hydrogel microgel n-isopropylacrylamide thermal sensitivity ph sensitivity heterophase polymerisation |
author_facet |
Vyacheslav A. Kuznetsov |
author_sort |
Vyacheslav A. Kuznetsov |
title |
Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review) |
title_short |
Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review) |
title_full |
Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review) |
title_fullStr |
Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review) |
title_full_unstemmed |
Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review) |
title_sort |
modern approaches to the medical use of ph- and temperature-sensitive copolymer hydrogels (review) |
publisher |
Voronezh State University |
series |
Конденсированные среды и межфазные границы |
issn |
1606-867X 1606-867X |
publishDate |
2020-12-01 |
description |
This article provides the review of the medical use of pH- and temperature-sensitive polymer hydrogels. Such polymers are characterised by their thermal and pH sensitivity in aqueous solutions at the functioning temperature of living organisms and can react to the slightest changes in environmental conditions. Due to these properties, they are called stimuli-sensitive polymers. This response to an external stimulus occurs due to the amphiphilicity (diphilicity) of these (co)polymers. The term hydrogels includes several concepts of macrogels and microgels. Microgels, unlike macrogels, are polymer particles dispersed in a liquid and are nano- or micro-objects. The review presents studies reflecting the main methods of obtaining
such polymeric materials, including precipitation polymerisation, as the main, simplest, and most accessible method for mini-emulsion polymerisation, microfluidics, and layer-by-layer adsorption of polyelectrolytes. Such systems will undoubtedly be promising for use in biotechnology and medicine due to the fact that they are liquid-swollen particles capable of binding and carrying various low to high molecular weight substances. It is also important that slight heating and cooling or a slight change in the pH of the medium shifts the system from a homogeneous to a heterogeneous state and vice versa. This provides
the opportunity to use these polymers as a means of targeted drug delivery, thereby reducing the negative effect of toxic substances used for treatment on the entire body and directing the action to a specific point. In addition, such polymers can be used to create smart coatings of implanted materials, as well as an artificial matrix for cell and tissue regeneration, contributing to a significant increase in the survival rate and regeneration rate of cells and tissues. |
topic |
hydrogel microgel n-isopropylacrylamide thermal sensitivity ph sensitivity heterophase polymerisation |
url |
https://journals.vsu.ru/kcmf/article/view/3113 |
work_keys_str_mv |
AT vyacheslavakuznetsov modernapproachestothemedicaluseofphandtemperaturesensitivecopolymerhydrogelsreview |
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