Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization
Since the novel coronavirus disease 2019 (COVID-19) has declared pandemic, the possibility of recurrence of the disease after recovery has become a debated issue. We report a case of an 84-yearsold male patient who was admitted to our hospital for dyspnea and fever. Lab and clinical workout showed...
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doaj-b5ef3526d5c345b4863f9303d61a128a2021-02-03T05:58:15ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522021-01-01AOP10.4081/itjm.2021.1393Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativizationChiara Vassallo0Francesca Pupo1Luca Marri2Chiara Schiavi3Francesca Giusti4Monica Greco5Simone Negrini6Raffaele De Palma7Andrea Guastalla8Department of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of GenoaDepartment of Clinical Immunology, IRCCS-San Martino University Hospital, University of Genoa Since the novel coronavirus disease 2019 (COVID-19) has declared pandemic, the possibility of recurrence of the disease after recovery has become a debated issue. We report a case of an 84-yearsold male patient who was admitted to our hospital for dyspnea and fever. Lab and clinical workout showed that he had COVID-19. After a full recovery of symptoms and a double negative nasopharyngeal swab of SARS-CoV-2 by RT-PCR assay, he was dismissed from the hospital. One month later, he developed again dyspnea and fever with lung involvement. Surprisingly, nasopharyngeal swab of SARS-CoV-2 was positive. Since he denied contacts with confirmed or suspected cases of COVID-19, he probably experienced a reactivation of a persistent infection. The failed eradication of the virus could depend on both virus’ escape mechanisms and dysfunctional immune response. Further studies are needed to confirm the hypothesis of viral reactivation and to identify signs of an incomplete clearance. https://www.italjmed.org/index.php/ijm/article/view/1393COVID-19viral testpneumoniaviral clearance. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiara Vassallo Francesca Pupo Luca Marri Chiara Schiavi Francesca Giusti Monica Greco Simone Negrini Raffaele De Palma Andrea Guastalla |
spellingShingle |
Chiara Vassallo Francesca Pupo Luca Marri Chiara Schiavi Francesca Giusti Monica Greco Simone Negrini Raffaele De Palma Andrea Guastalla Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization Italian Journal of Medicine COVID-19 viral test pneumonia viral clearance. |
author_facet |
Chiara Vassallo Francesca Pupo Luca Marri Chiara Schiavi Francesca Giusti Monica Greco Simone Negrini Raffaele De Palma Andrea Guastalla |
author_sort |
Chiara Vassallo |
title |
Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization |
title_short |
Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization |
title_full |
Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization |
title_fullStr |
Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization |
title_full_unstemmed |
Recurrence of COVID-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization |
title_sort |
recurrence of covid-19 related symptoms and viral detection in patient discharged after complete recovery and test negativization |
publisher |
PAGEPress Publications |
series |
Italian Journal of Medicine |
issn |
1877-9344 1877-9352 |
publishDate |
2021-01-01 |
description |
Since the novel coronavirus disease 2019 (COVID-19) has declared pandemic, the possibility of recurrence of the disease after recovery has become a debated issue. We report a case of an 84-yearsold male patient who was admitted to our hospital for dyspnea and fever. Lab and clinical workout showed that he had COVID-19. After a full recovery of symptoms and a double negative nasopharyngeal swab of SARS-CoV-2 by RT-PCR assay, he was dismissed from the hospital. One month later, he developed again dyspnea and fever with lung involvement. Surprisingly, nasopharyngeal swab of SARS-CoV-2 was positive. Since he denied contacts with confirmed or suspected cases of COVID-19, he probably experienced a reactivation of a persistent infection. The failed eradication of the virus could depend on both virus’ escape mechanisms and dysfunctional immune response. Further studies are needed to confirm the hypothesis of viral reactivation and to identify signs of an incomplete clearance.
|
topic |
COVID-19 viral test pneumonia viral clearance. |
url |
https://www.italjmed.org/index.php/ijm/article/view/1393 |
work_keys_str_mv |
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