Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA duplex through a transient enzyme-bridged break in another (gated helix) followed by ligation of the break by TOP2. A TOP2 poison, etoposide blocks T...

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Bibliographic Details
Main Authors: Suguru Morimoto, Masataka Tsuda, Heeyoun Bunch, Hiroyuki Sasanuma, Caroline Austin, Shunichi Takeda
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Genes
Subjects:
topoisomerase ii
genotoxicity
cell cycle
estrogen
breast cancer
transcription
brca1
brca2
Online Access:https://www.mdpi.com/2073-4425/10/11/868

Internet

https://www.mdpi.com/2073-4425/10/11/868

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