Bile cast nephropathy: when the kidneys turn yellow
Abstract Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tub...
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Series: | Renal Replacement Therapy |
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Online Access: | http://link.springer.com/article/10.1186/s41100-020-00265-0 |
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doaj-b60c687ec80a4088bf157ae3cf3ab79c2020-11-25T03:01:38ZengBMCRenal Replacement Therapy2059-13812020-03-01611710.1186/s41100-020-00265-0Bile cast nephropathy: when the kidneys turn yellowAlissar El Chediak0Khaled Janom1Sahar H. Koubar2Department of Internal Medicine, American University of BeirutDepartment of Internal Medicine, Detroit Medical Center/Wayne State UniversityDepartment of Internal Medicine, Division of Nephrology, Faculty of Medicine, American University of BeirutAbstract Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. Bile cast nephropathy has characteristic histopathological changes consisting of bilirubin cast deposition in the distal nephron along with tubular epithelial cell injury. Treatment is based on the reversal of liver injury. This review aims to describe bile cast nephropathy in terms of its clinical and morphological features and to shed light on diagnostic techniques. In addition, we present data on management of such nephropathy while reviewing all the reported cases of bile cast nephropathy.http://link.springer.com/article/10.1186/s41100-020-00265-0Bile cast nephropathyCholemic nephropathyHyperbilirubinemiaExtracorporeal therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alissar El Chediak Khaled Janom Sahar H. Koubar |
spellingShingle |
Alissar El Chediak Khaled Janom Sahar H. Koubar Bile cast nephropathy: when the kidneys turn yellow Renal Replacement Therapy Bile cast nephropathy Cholemic nephropathy Hyperbilirubinemia Extracorporeal therapy |
author_facet |
Alissar El Chediak Khaled Janom Sahar H. Koubar |
author_sort |
Alissar El Chediak |
title |
Bile cast nephropathy: when the kidneys turn yellow |
title_short |
Bile cast nephropathy: when the kidneys turn yellow |
title_full |
Bile cast nephropathy: when the kidneys turn yellow |
title_fullStr |
Bile cast nephropathy: when the kidneys turn yellow |
title_full_unstemmed |
Bile cast nephropathy: when the kidneys turn yellow |
title_sort |
bile cast nephropathy: when the kidneys turn yellow |
publisher |
BMC |
series |
Renal Replacement Therapy |
issn |
2059-1381 |
publishDate |
2020-03-01 |
description |
Abstract Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. Bile cast nephropathy has characteristic histopathological changes consisting of bilirubin cast deposition in the distal nephron along with tubular epithelial cell injury. Treatment is based on the reversal of liver injury. This review aims to describe bile cast nephropathy in terms of its clinical and morphological features and to shed light on diagnostic techniques. In addition, we present data on management of such nephropathy while reviewing all the reported cases of bile cast nephropathy. |
topic |
Bile cast nephropathy Cholemic nephropathy Hyperbilirubinemia Extracorporeal therapy |
url |
http://link.springer.com/article/10.1186/s41100-020-00265-0 |
work_keys_str_mv |
AT alissarelchediak bilecastnephropathywhenthekidneysturnyellow AT khaledjanom bilecastnephropathywhenthekidneysturnyellow AT saharhkoubar bilecastnephropathywhenthekidneysturnyellow |
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