Innate immunity to infection in the lower female genital tract
Due to the contact with the external environment, the lower female genital tract is non-sterile. The innate immune system has evolved many mechanisms to protect vaginal tissues from pathogens at the same time allowing for survival of the comensal flora. Innate immunity in the lower female genital tr...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Index Copernicus International S.A.
2013-05-01
|
Series: | Postępy Higieny i Medycyny Doświadczalnej |
Subjects: | |
Online Access: | http://journals.indexcopernicus.com/fulltxt.php?ICID=1048816 |
id |
doaj-b61be9c597bf4ecfa9191e69493b4898 |
---|---|
record_format |
Article |
spelling |
doaj-b61be9c597bf4ecfa9191e69493b48982020-11-25T02:43:57ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932013-05-0167863688388401Innate immunity to infection in the lower female genital tract Karolina Paulina GregorczykMałgorzata KrzyżowskaDue to the contact with the external environment, the lower female genital tract is non-sterile. The innate immune system has evolved many mechanisms to protect vaginal tissues from pathogens at the same time allowing for survival of the comensal flora. Innate immunity in the lower female genital tract undergoes hormonal regulation. Estrogen and progesterone levels also influence the vaginal mucosal epithelium remodeling with the neutrophlis playing a crucial role, as the most numerous leukocytes in the vaginal tissue. Being exposed to the environment, the vaginal epithelium consists a physical barrier for pathogens, but it also shows the presence of MHC class I and pattern recognition receptors. By production of cytokines and chemokines, the vaginal epithelium attracts innate immune cells such as neutrophiles, macrophages, dendritic cells or NK cells. Vaginal comensal flora is another important mechanism of innate immunity by production of lactic acid and hydrogen peroxide, inhibiting pathogen’s growth. Disturbances of vaginal microflora can result in pathogenic infections such as bacterial vaginosis or candidosis. Together with herpes genitalis, HPV infection, chlamydiosis, trichomatosis and gonorrhoea, vaginal infections increase the risk of acquiring another sexually transmitted disease, includig HIV due to the impaired mucosal integrity, facilitating for tissue penetration by pathogens and development of local inflammation.http://journals.indexcopernicus.com/fulltxt.php?ICID=1048816lower female genital tractinnate immunityNeutrophilsEpithelial CellsToll-Like Receptorsbacterial microfloradolny odcinek żeńskich narządów płciowychwrodzony układ odporności |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karolina Paulina Gregorczyk Małgorzata Krzyżowska |
spellingShingle |
Karolina Paulina Gregorczyk Małgorzata Krzyżowska Innate immunity to infection in the lower female genital tract Postępy Higieny i Medycyny Doświadczalnej lower female genital tract innate immunity Neutrophils Epithelial Cells Toll-Like Receptors bacterial microflora dolny odcinek żeńskich narządów płciowych wrodzony układ odporności |
author_facet |
Karolina Paulina Gregorczyk Małgorzata Krzyżowska |
author_sort |
Karolina Paulina Gregorczyk |
title |
Innate immunity to infection in the lower female genital tract |
title_short |
Innate immunity to infection in the lower female genital tract |
title_full |
Innate immunity to infection in the lower female genital tract |
title_fullStr |
Innate immunity to infection in the lower female genital tract |
title_full_unstemmed |
Innate immunity to infection in the lower female genital tract |
title_sort |
innate immunity to infection in the lower female genital tract |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2013-05-01 |
description |
Due to the contact with the external environment, the lower female genital tract is non-sterile. The innate immune system has evolved many mechanisms to protect vaginal tissues from pathogens at the same time allowing for survival of the comensal flora. Innate immunity in the lower female genital tract undergoes hormonal regulation. Estrogen and progesterone levels also influence the vaginal mucosal epithelium remodeling with the neutrophlis playing a crucial role, as the most numerous leukocytes in the vaginal tissue. Being exposed to the environment, the vaginal epithelium consists a physical barrier for pathogens, but it also shows the presence of MHC class I and pattern recognition receptors. By production of cytokines and chemokines, the vaginal epithelium attracts innate immune cells such as neutrophiles, macrophages, dendritic cells or NK cells. Vaginal comensal flora is another important mechanism of innate immunity by production of lactic acid and hydrogen peroxide, inhibiting pathogen’s growth. Disturbances of vaginal microflora can result in pathogenic infections such as bacterial vaginosis or candidosis. Together with herpes genitalis, HPV infection, chlamydiosis, trichomatosis and gonorrhoea, vaginal infections increase the risk of acquiring another sexually transmitted disease, includig HIV due to the impaired mucosal integrity, facilitating for tissue penetration by pathogens and development of local inflammation. |
topic |
lower female genital tract innate immunity Neutrophils Epithelial Cells Toll-Like Receptors bacterial microflora dolny odcinek żeńskich narządów płciowych wrodzony układ odporności |
url |
http://journals.indexcopernicus.com/fulltxt.php?ICID=1048816 |
work_keys_str_mv |
AT karolinapaulinagregorczyk innateimmunitytoinfectioninthelowerfemalegenitaltract AT małgorzatakrzyzowska innateimmunitytoinfectioninthelowerfemalegenitaltract |
_version_ |
1724768467087785984 |