EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology
Introduction: Previous studies on electroencephalography (EEG) to discriminate between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) have been promising. These studies did not consider the pathological overlap of the two diseases. DLB-patients with concomitant AD pathology (DLB/AD+) h...
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doaj-b6311473d470496fb32450c5aab7b6cb2020-11-24T20:49:46ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-07-011010.3389/fnagi.2018.00190361585EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed PathologyJessica J. van der Zande0Alida A. Gouw1Alida A. Gouw2Inger van Steenoven3Philip Scheltens4Cornelis Jan Stam5Afina W. LemstraVU Medical Center Alzheimer Center, Amsterdam, NetherlandsVU Medical Center Alzheimer Center, Amsterdam, NetherlandsDepartment of Clinical Neurophysiology, VU Medical Center, Amsterdam, NetherlandsVU Medical Center Alzheimer Center, Amsterdam, NetherlandsVU Medical Center Alzheimer Center, Amsterdam, NetherlandsDepartment of Clinical Neurophysiology, VU Medical Center, Amsterdam, NetherlandsIntroduction: Previous studies on electroencephalography (EEG) to discriminate between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) have been promising. These studies did not consider the pathological overlap of the two diseases. DLB-patients with concomitant AD pathology (DLB/AD+) have a more severe disease manifestation. The EEG may also be influenced by a synergistic effect of the two pathologies. We aimed to compare EEG characteristics between DLB/AD+, “pure” DLB (DLB/AD−) and AD.Methods: We selected probable DLB patients who had an EEG and cerebrospinal fluid (CSF) available, from the Amsterdam Dementia Cohort (ADC). Concomitant AD-pathology was defined as a CSF tau/Aβ-42 ratio > 0.52. Forty-one DLB/AD+ cases were matched for age (mean 70 (range 53–85)) and sex (85% male) 1:1 to DLB/AD− and AD-patients. EEGs were assessed visually, with Fast Fourier Transform (FFT), network- and connectivity measures.Results: EEG visual severity score (range 1–5) did not differ between DLB/AD− and DLB/AD+ (2.7 in both groups) and was higher compared to AD (1.9, p < 0.01). Both DLB groups had a lower peak frequency (7.0 Hz and 6.9 Hz in DLB vs. 8.2 in AD, p < 0.05), more slow-wave activity and more prominent disruptions of connectivity and networks, compared to AD. No significant differences were found between DLB/AD+ and DLB/AD−.Discussion: EEG abnormalities are more pronounced in DLB, regardless of AD co-pathology. This emphasizes the valuable role of EEG in discriminating between DLB and AD. It suggests that EEG slowing in DLB is influenced more by the α-synucleinopathy, or the associated cholinergic deficit, than by amyloid and tau pathology.https://www.frontiersin.org/article/10.3389/fnagi.2018.00190/fulldementia with Lewy bodies (DLB)Alzheimer’s disease (AD)EEGspectral analysisdifferential diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jessica J. van der Zande Alida A. Gouw Alida A. Gouw Inger van Steenoven Philip Scheltens Cornelis Jan Stam Afina W. Lemstra |
spellingShingle |
Jessica J. van der Zande Alida A. Gouw Alida A. Gouw Inger van Steenoven Philip Scheltens Cornelis Jan Stam Afina W. Lemstra EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology Frontiers in Aging Neuroscience dementia with Lewy bodies (DLB) Alzheimer’s disease (AD) EEG spectral analysis differential diagnosis |
author_facet |
Jessica J. van der Zande Alida A. Gouw Alida A. Gouw Inger van Steenoven Philip Scheltens Cornelis Jan Stam Afina W. Lemstra |
author_sort |
Jessica J. van der Zande |
title |
EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology |
title_short |
EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology |
title_full |
EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology |
title_fullStr |
EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology |
title_full_unstemmed |
EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology |
title_sort |
eeg characteristics of dementia with lewy bodies, alzheimer’s disease and mixed pathology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2018-07-01 |
description |
Introduction: Previous studies on electroencephalography (EEG) to discriminate between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) have been promising. These studies did not consider the pathological overlap of the two diseases. DLB-patients with concomitant AD pathology (DLB/AD+) have a more severe disease manifestation. The EEG may also be influenced by a synergistic effect of the two pathologies. We aimed to compare EEG characteristics between DLB/AD+, “pure” DLB (DLB/AD−) and AD.Methods: We selected probable DLB patients who had an EEG and cerebrospinal fluid (CSF) available, from the Amsterdam Dementia Cohort (ADC). Concomitant AD-pathology was defined as a CSF tau/Aβ-42 ratio > 0.52. Forty-one DLB/AD+ cases were matched for age (mean 70 (range 53–85)) and sex (85% male) 1:1 to DLB/AD− and AD-patients. EEGs were assessed visually, with Fast Fourier Transform (FFT), network- and connectivity measures.Results: EEG visual severity score (range 1–5) did not differ between DLB/AD− and DLB/AD+ (2.7 in both groups) and was higher compared to AD (1.9, p < 0.01). Both DLB groups had a lower peak frequency (7.0 Hz and 6.9 Hz in DLB vs. 8.2 in AD, p < 0.05), more slow-wave activity and more prominent disruptions of connectivity and networks, compared to AD. No significant differences were found between DLB/AD+ and DLB/AD−.Discussion: EEG abnormalities are more pronounced in DLB, regardless of AD co-pathology. This emphasizes the valuable role of EEG in discriminating between DLB and AD. It suggests that EEG slowing in DLB is influenced more by the α-synucleinopathy, or the associated cholinergic deficit, than by amyloid and tau pathology. |
topic |
dementia with Lewy bodies (DLB) Alzheimer’s disease (AD) EEG spectral analysis differential diagnosis |
url |
https://www.frontiersin.org/article/10.3389/fnagi.2018.00190/full |
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