Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients
Abstract Background Asymptomatic carotid artery stenosis (aCAS) impairs haemodynamic and cognitive functions; however, the relationship between these changes and brain network connectivity remains largely unknown. This study aimed to determine the relationship between functional connectivity and neu...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-09-01
|
Series: | BMC Neurology |
Online Access: | https://doi.org/10.1186/s12883-021-02385-4 |
id |
doaj-b634c421f6004ceca405905e8d8834bb |
---|---|
record_format |
Article |
spelling |
doaj-b634c421f6004ceca405905e8d8834bb2021-09-19T11:17:46ZengBMCBMC Neurology1471-23772021-09-012111810.1186/s12883-021-02385-4Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patientsShihao He0Ran Duan1Ziqi Liu2Cai Zhang3Tian Li4Yanchang Wei5Ning Ma6Rong Wang7Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Peking University International HospitalDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityCollaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal UniversityCollaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background Asymptomatic carotid artery stenosis (aCAS) impairs haemodynamic and cognitive functions; however, the relationship between these changes and brain network connectivity remains largely unknown. This study aimed to determine the relationship between functional connectivity and neurocognition in patients with aCAS. Methods We compared functional status in 14 patients with aCAS and 15 healthy controls using resting state functional magnetic resonance imaging sequences. The subjects underwent a full range of neuropsychological tests and a graphical theoretical analysis of their brain networks. Results Compared with controls, patients with aCAS showed significant decline in neuropsychological functions, particularly short-term memory (word-memory, p = .046 and picture-memory, p = .014). Brain network connectivity was lower in patients with aCAS than in the controls, and the decline of functional connectivity in aCAS patients was mainly concentrated in the left and right inferior frontal gyri, temporal lobe, left cingulate gyrus, and hippocampus. Decreased connectivity between various brain regions was significantly correlated with impaired short-term memory. Patients with aCAS showed cognitive impairment independent of known vascular risk factors for vascular cognitive impairment. The cognitive defects were mainly manifested in the short-term memory of words and pictures. Conclusions This study is the first of its kind to identify an association between disruption of functional connections in left carotid stenosis and impairment of short-term memory. The findings suggest that alterations in network connectivity may be an essential mechanism underlying cognitive decline in aCAS patients. Clinical trial registration-URL Unique identifier: 04/06/2019, ChiCTR1900023610 .https://doi.org/10.1186/s12883-021-02385-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shihao He Ran Duan Ziqi Liu Cai Zhang Tian Li Yanchang Wei Ning Ma Rong Wang |
spellingShingle |
Shihao He Ran Duan Ziqi Liu Cai Zhang Tian Li Yanchang Wei Ning Ma Rong Wang Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients BMC Neurology |
author_facet |
Shihao He Ran Duan Ziqi Liu Cai Zhang Tian Li Yanchang Wei Ning Ma Rong Wang |
author_sort |
Shihao He |
title |
Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients |
title_short |
Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients |
title_full |
Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients |
title_fullStr |
Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients |
title_full_unstemmed |
Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients |
title_sort |
altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2021-09-01 |
description |
Abstract Background Asymptomatic carotid artery stenosis (aCAS) impairs haemodynamic and cognitive functions; however, the relationship between these changes and brain network connectivity remains largely unknown. This study aimed to determine the relationship between functional connectivity and neurocognition in patients with aCAS. Methods We compared functional status in 14 patients with aCAS and 15 healthy controls using resting state functional magnetic resonance imaging sequences. The subjects underwent a full range of neuropsychological tests and a graphical theoretical analysis of their brain networks. Results Compared with controls, patients with aCAS showed significant decline in neuropsychological functions, particularly short-term memory (word-memory, p = .046 and picture-memory, p = .014). Brain network connectivity was lower in patients with aCAS than in the controls, and the decline of functional connectivity in aCAS patients was mainly concentrated in the left and right inferior frontal gyri, temporal lobe, left cingulate gyrus, and hippocampus. Decreased connectivity between various brain regions was significantly correlated with impaired short-term memory. Patients with aCAS showed cognitive impairment independent of known vascular risk factors for vascular cognitive impairment. The cognitive defects were mainly manifested in the short-term memory of words and pictures. Conclusions This study is the first of its kind to identify an association between disruption of functional connections in left carotid stenosis and impairment of short-term memory. The findings suggest that alterations in network connectivity may be an essential mechanism underlying cognitive decline in aCAS patients. Clinical trial registration-URL Unique identifier: 04/06/2019, ChiCTR1900023610 . |
url |
https://doi.org/10.1186/s12883-021-02385-4 |
work_keys_str_mv |
AT shihaohe alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT randuan alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT ziqiliu alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT caizhang alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT tianli alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT yanchangwei alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT ningma alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients AT rongwang alteredfunctionalconnectivityisrelatedtoimpairedcognitioninleftunilateralasymptomaticcarotidarterystenosispatients |
_version_ |
1717375896379195392 |