Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia
Abstract Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We cond...
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doaj-b634ed7b93154f279d559952fc5d87022020-12-13T12:35:07ZengNature Publishing GroupScientific Reports2045-23222020-12-0110111510.1038/s41598-020-78493-xBiomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemiaSophia Morel0Pauline Léveillé1Mariia Samoilenko2Anita Franco3Jade England4Nicolas Malaquin5Véronique Tu6Guillaume B. Cardin7Simon Drouin8Francis Rodier9Sarah Lippé10Maja Krajinovic11Caroline Laverdière12Daniel Sinnett13Geneviève Lefebvre14Emile Levy15Valérie Marcil16Research Centre of Sainte-Justine University Health Center, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalCRCHUM and Institut du Cancer de MontréalCRCHUM and Institut du Cancer de MontréalCRCHUM and Institut du Cancer de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalCRCHUM and Institut du Cancer de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalDepartment of Pediatrics, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalDepartment of Mathematics, Université du Québec à MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalResearch Centre of Sainte-Justine University Health Center, Université de MontréalAbstract Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 ± 6.3 years; mean time since diagnosis, 15.5 ± 5.2 years) and evaluated the associations using a series of logistic regressions. Using structural equation models, we also tested if the relationship between endotoxemia and cardiometabolic complications was mediated by the latent (unobserved) variable inflammation inferred from the observed biomarkers CRP, TNF-α and IL-6. High leptin-adiponectin ratio was associated with obesity [adjusted OR = 15.7; 95% CI (6.2–39.7)], insulin resistance [20.6 (5.2–82.1)] and the metabolic syndrome [11.2 (2.6–48.7)]. Higher levels of plasminogen activator inhibitor-1 and tumor necrosis factor-α were associated with obesity [3.37 (1.6–7.1) and 2.34 (1.3–4.2), respectively] whereas high C-reactive protein levels were associated with insulin resistance [3.3 (1.6–6.8)], dyslipidemia [2.6 (1.4–4.9)] and MetS [6.5 (2.4–17.9)]. Our analyses provided evidence for a directional relationship between lipopolysaccharide binding protein, related to metabolic endotoxemia, inflammation and cardiometabolic outcomes. Identification of biomarkers and biological mechanisms could open new avenues for prevention strategies to minimize the long-term sequelae, improve follow-up and optimize the quality of life of this high-risk population.https://doi.org/10.1038/s41598-020-78493-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sophia Morel Pauline Léveillé Mariia Samoilenko Anita Franco Jade England Nicolas Malaquin Véronique Tu Guillaume B. Cardin Simon Drouin Francis Rodier Sarah Lippé Maja Krajinovic Caroline Laverdière Daniel Sinnett Geneviève Lefebvre Emile Levy Valérie Marcil |
spellingShingle |
Sophia Morel Pauline Léveillé Mariia Samoilenko Anita Franco Jade England Nicolas Malaquin Véronique Tu Guillaume B. Cardin Simon Drouin Francis Rodier Sarah Lippé Maja Krajinovic Caroline Laverdière Daniel Sinnett Geneviève Lefebvre Emile Levy Valérie Marcil Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia Scientific Reports |
author_facet |
Sophia Morel Pauline Léveillé Mariia Samoilenko Anita Franco Jade England Nicolas Malaquin Véronique Tu Guillaume B. Cardin Simon Drouin Francis Rodier Sarah Lippé Maja Krajinovic Caroline Laverdière Daniel Sinnett Geneviève Lefebvre Emile Levy Valérie Marcil |
author_sort |
Sophia Morel |
title |
Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia |
title_short |
Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia |
title_full |
Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia |
title_fullStr |
Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia |
title_full_unstemmed |
Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia |
title_sort |
biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-12-01 |
description |
Abstract Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 ± 6.3 years; mean time since diagnosis, 15.5 ± 5.2 years) and evaluated the associations using a series of logistic regressions. Using structural equation models, we also tested if the relationship between endotoxemia and cardiometabolic complications was mediated by the latent (unobserved) variable inflammation inferred from the observed biomarkers CRP, TNF-α and IL-6. High leptin-adiponectin ratio was associated with obesity [adjusted OR = 15.7; 95% CI (6.2–39.7)], insulin resistance [20.6 (5.2–82.1)] and the metabolic syndrome [11.2 (2.6–48.7)]. Higher levels of plasminogen activator inhibitor-1 and tumor necrosis factor-α were associated with obesity [3.37 (1.6–7.1) and 2.34 (1.3–4.2), respectively] whereas high C-reactive protein levels were associated with insulin resistance [3.3 (1.6–6.8)], dyslipidemia [2.6 (1.4–4.9)] and MetS [6.5 (2.4–17.9)]. Our analyses provided evidence for a directional relationship between lipopolysaccharide binding protein, related to metabolic endotoxemia, inflammation and cardiometabolic outcomes. Identification of biomarkers and biological mechanisms could open new avenues for prevention strategies to minimize the long-term sequelae, improve follow-up and optimize the quality of life of this high-risk population. |
url |
https://doi.org/10.1038/s41598-020-78493-x |
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