Insights in Anaphylaxis and Clonal Mast Cell Disorders
The prevalence of anaphylaxis among patients with clonal mast cell disorders (MCD) is clearly higher comparing to the general population. Due to a lower frequency of symptoms outside of acute episodes, clonal MCD in the absence of skin lesions might sometimes be difficult to identify which may lead...
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2017-07-01
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doaj-b638d9fd6f9f4b0090ad6ccc88827b6c2020-11-24T21:00:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-07-01810.3389/fimmu.2017.00792269158Insights in Anaphylaxis and Clonal Mast Cell DisordersDavid González-de-Olano0Iván Álvarez-Twose1Allergy Department, Hospital Universitario Ramón y Cajal, Madrid, SpainInstituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast), Hospital Virgen del Valle, Toledo, SpainThe prevalence of anaphylaxis among patients with clonal mast cell disorders (MCD) is clearly higher comparing to the general population. Due to a lower frequency of symptoms outside of acute episodes, clonal MCD in the absence of skin lesions might sometimes be difficult to identify which may lead to underdiagnosis, and anaphylaxis is commonly the presenting symptom in these patients. Although the release of mast cell (MC) mediators upon MC activation might present with a wide variety of symptoms, particular clinical features typically characterize MC mediator release episodes in patients with clonal MCD without skin involvement. Final diagnosis requires a bone marrow study, and it is recommended that this should be done in reference centers. In this article, we address the main triggers for anaphylaxis, risk factors, clinical presentation, diagnosis, and management of patients with MC activation syndromes (MCASs), with special emphasis on clonal MCAS [systemic mastocytosis and mono(clonal) MC activations syndromes].http://journal.frontiersin.org/article/10.3389/fimmu.2017.00792/fullanaphylaxisclonalmast cellmast cell activation syndromemastocytosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David González-de-Olano Iván Álvarez-Twose |
spellingShingle |
David González-de-Olano Iván Álvarez-Twose Insights in Anaphylaxis and Clonal Mast Cell Disorders Frontiers in Immunology anaphylaxis clonal mast cell mast cell activation syndrome mastocytosis |
author_facet |
David González-de-Olano Iván Álvarez-Twose |
author_sort |
David González-de-Olano |
title |
Insights in Anaphylaxis and Clonal Mast Cell Disorders |
title_short |
Insights in Anaphylaxis and Clonal Mast Cell Disorders |
title_full |
Insights in Anaphylaxis and Clonal Mast Cell Disorders |
title_fullStr |
Insights in Anaphylaxis and Clonal Mast Cell Disorders |
title_full_unstemmed |
Insights in Anaphylaxis and Clonal Mast Cell Disorders |
title_sort |
insights in anaphylaxis and clonal mast cell disorders |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2017-07-01 |
description |
The prevalence of anaphylaxis among patients with clonal mast cell disorders (MCD) is clearly higher comparing to the general population. Due to a lower frequency of symptoms outside of acute episodes, clonal MCD in the absence of skin lesions might sometimes be difficult to identify which may lead to underdiagnosis, and anaphylaxis is commonly the presenting symptom in these patients. Although the release of mast cell (MC) mediators upon MC activation might present with a wide variety of symptoms, particular clinical features typically characterize MC mediator release episodes in patients with clonal MCD without skin involvement. Final diagnosis requires a bone marrow study, and it is recommended that this should be done in reference centers. In this article, we address the main triggers for anaphylaxis, risk factors, clinical presentation, diagnosis, and management of patients with MC activation syndromes (MCASs), with special emphasis on clonal MCAS [systemic mastocytosis and mono(clonal) MC activations syndromes]. |
topic |
anaphylaxis clonal mast cell mast cell activation syndrome mastocytosis |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00792/full |
work_keys_str_mv |
AT davidgonzalezdeolano insightsinanaphylaxisandclonalmastcelldisorders AT ivanalvareztwose insightsinanaphylaxisandclonalmastcelldisorders |
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1716779784900444160 |