Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

Abstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast op...

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Bibliographic Details
Main Authors: José Rodríguez-Aguilar, Beatriz Ordóñez, Matías Vidal, Marcos Caroli Rezende, Moisés Domínguez
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2017-03-01
Series:SynOpen
Subjects:
suzuki–miyaura coupling
pyrimidines
tosylates
microwave-accelerated synthesis
cross-coupling
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588810
Description
Summary:Abstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast option for the synthesis of these heterocyclic systems.
ISSN:2509-9396

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