Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

Abstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast op...

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Main Authors: José Rodríguez-Aguilar, Beatriz Ordóñez, Matías Vidal, Marcos Caroli Rezende, Moisés Domínguez
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2017-03-01
Series:SynOpen
Subjects:
suzuki–miyaura coupling
pyrimidines
tosylates
microwave-accelerated synthesis
cross-coupling
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588810
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spelling doaj-b6443a597c94415da133bc01e4411b2c2020-11-25T03:12:45ZengGeorg Thieme Verlag KGSynOpen2509-93962017-03-0101010024002810.1055/s-0036-1588810Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in WaterJosé Rodríguez-AguilarBeatriz OrdóñezMatías VidalMarcos Caroli RezendeMoisés DomínguezAbstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast option for the synthesis of these heterocyclic systems.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588810suzuki–miyaura couplingpyrimidinestosylatesmicrowave-accelerated synthesiscross-coupling
collection DOAJ
language English
format Article
sources DOAJ
author José Rodríguez-Aguilar
Beatriz Ordóñez
Matías Vidal
Marcos Caroli Rezende
Moisés Domínguez
spellingShingle José Rodríguez-Aguilar
Beatriz Ordóñez
Matías Vidal
Marcos Caroli Rezende
Moisés Domínguez
Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water
SynOpen
suzuki–miyaura coupling
pyrimidines
tosylates
microwave-accelerated synthesis
cross-coupling
author_facet José Rodríguez-Aguilar
Beatriz Ordóñez
Matías Vidal
Marcos Caroli Rezende
Moisés Domínguez
author_sort José Rodríguez-Aguilar
title Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water
title_short Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water
title_full Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water
title_fullStr Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water
title_full_unstemmed Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water
title_sort microwave-promoted synthesis of 4-arylpyrimidines by pd-catalysed suzuki–miyaura coupling of 4-pyrimidyl tosylates in water
publisher Georg Thieme Verlag KG
series SynOpen
issn 2509-9396
publishDate 2017-03-01
description Abstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast option for the synthesis of these heterocyclic systems.
topic suzuki–miyaura coupling
pyrimidines
tosylates
microwave-accelerated synthesis
cross-coupling
url http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588810
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AT beatrizordonez microwavepromotedsynthesisof4arylpyrimidinesbypdcatalysedsuzukimiyauracouplingof4pyrimidyltosylatesinwater
AT matiasvidal microwavepromotedsynthesisof4arylpyrimidinesbypdcatalysedsuzukimiyauracouplingof4pyrimidyltosylatesinwater
AT marcoscarolirezende microwavepromotedsynthesisof4arylpyrimidinesbypdcatalysedsuzukimiyauracouplingof4pyrimidyltosylatesinwater
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