Lung-On-A-Chip Technologies for Disease Modeling and Drug Development
Animal and two-dimensional cell culture models have had a profound impact on not only lung research but also medical research at large, despite inherent flaws and differences when compared with in vivo and clinical observations. Three-dimensional (3D) tissue models are a natural progression and exte...
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doaj-b6479268b13048caaa9d2f1815ee60e82020-11-25T03:18:54ZengSAGE PublishingBiomedical Engineering and Computational Biology1179-59722016-01-017s110.4137/BECB.S34252Lung-On-A-Chip Technologies for Disease Modeling and Drug DevelopmentDipasri Konar0Mahesh Devarasetty1Didem V. Yildiz2Anthony Atala3Sean V. Murphy4Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Animal and two-dimensional cell culture models have had a profound impact on not only lung research but also medical research at large, despite inherent flaws and differences when compared with in vivo and clinical observations. Three-dimensional (3D) tissue models are a natural progression and extension of existing techniques that seek to plug the gaps and mitigate the drawbacks of two-dimensional and animal technologies. In this review, we describe the transition of historic models to contemporary 3D cell and organoid models, the varieties of current 3D cell and tissue culture modalities, the common methods for imaging these models, and finally, the applications of these models and imaging techniques to lung research.https://doi.org/10.4137/BECB.S34252 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dipasri Konar Mahesh Devarasetty Didem V. Yildiz Anthony Atala Sean V. Murphy |
spellingShingle |
Dipasri Konar Mahesh Devarasetty Didem V. Yildiz Anthony Atala Sean V. Murphy Lung-On-A-Chip Technologies for Disease Modeling and Drug Development Biomedical Engineering and Computational Biology |
author_facet |
Dipasri Konar Mahesh Devarasetty Didem V. Yildiz Anthony Atala Sean V. Murphy |
author_sort |
Dipasri Konar |
title |
Lung-On-A-Chip Technologies for Disease Modeling and Drug Development |
title_short |
Lung-On-A-Chip Technologies for Disease Modeling and Drug Development |
title_full |
Lung-On-A-Chip Technologies for Disease Modeling and Drug Development |
title_fullStr |
Lung-On-A-Chip Technologies for Disease Modeling and Drug Development |
title_full_unstemmed |
Lung-On-A-Chip Technologies for Disease Modeling and Drug Development |
title_sort |
lung-on-a-chip technologies for disease modeling and drug development |
publisher |
SAGE Publishing |
series |
Biomedical Engineering and Computational Biology |
issn |
1179-5972 |
publishDate |
2016-01-01 |
description |
Animal and two-dimensional cell culture models have had a profound impact on not only lung research but also medical research at large, despite inherent flaws and differences when compared with in vivo and clinical observations. Three-dimensional (3D) tissue models are a natural progression and extension of existing techniques that seek to plug the gaps and mitigate the drawbacks of two-dimensional and animal technologies. In this review, we describe the transition of historic models to contemporary 3D cell and organoid models, the varieties of current 3D cell and tissue culture modalities, the common methods for imaging these models, and finally, the applications of these models and imaging techniques to lung research. |
url |
https://doi.org/10.4137/BECB.S34252 |
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