The dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulation.

The dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulation.

Chaperonins are large ring shaped oligomers that facilitate protein folding by encapsulation within a central cavity. All chaperonins possess flexible C-termini which protrude from the equatorial domain of each subunit into the central cavity. Biochemical evidence suggests that the termini play an i...

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Bibliographic Details
Main Authors: Kevin M Dalton, Judith Frydman, Vijay S Pande
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4379175?pdf=render

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