Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containin...
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| Format: | Article |
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Hindawi Limited
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/8460603 |
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doaj-b670472724dd44b9845502fe06a8ab782020-11-24T21:00:32ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/84606038460603Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult MaleAngela Shaw0Miriam Morrell1Annikka Weissferdt2Andrea Hayes-Jordan3Douglas Harrison4Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USAMixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma.http://dx.doi.org/10.1155/2018/8460603 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Angela Shaw Miriam Morrell Annikka Weissferdt Andrea Hayes-Jordan Douglas Harrison |
| spellingShingle |
Angela Shaw Miriam Morrell Annikka Weissferdt Andrea Hayes-Jordan Douglas Harrison Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male Case Reports in Oncological Medicine |
| author_facet |
Angela Shaw Miriam Morrell Annikka Weissferdt Andrea Hayes-Jordan Douglas Harrison |
| author_sort |
Angela Shaw |
| title |
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male |
| title_short |
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male |
| title_full |
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male |
| title_fullStr |
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male |
| title_full_unstemmed |
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male |
| title_sort |
malignant transformation of testicular teratoma to pnet, adenocarcinoma, and osteosarcoma with complete remission after surgery and combination chemotherapy in a young adult male |
| publisher |
Hindawi Limited |
| series |
Case Reports in Oncological Medicine |
| issn |
2090-6706 2090-6714 |
| publishDate |
2018-01-01 |
| description |
Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma. |
| url |
http://dx.doi.org/10.1155/2018/8460603 |
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