Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus
Transformation of a poorly differentiated squamous cell carcinoma (SCC) of the esophagus into a ''carcinosarcoma'' of the pleura and lung has never been reported and its histogenetic origin is still debated. A 48-year-old man was admitted due to progressive dysphagia and a weight...
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doaj-b67419d3640b40928cb3e5332ec865952020-11-25T02:13:58ZengElsevierHematology/Oncology and Stem Cell Therapy1658-38762010-01-01314750Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagusChien-Wen Chen0Kuan-Yu Chen1Chin-Jung Lin2Wann-Cherng Perng3Jia-Hong Chen4Chien-Wen Chen · Tri-Service General Hospital, Taipei, Taiwan; Tri-Service General Hospital, Taipei, TaiwanTri-Service General Hospital, Taipei, TaiwanTri-Service General Hospital, Taipei, TaiwanTri-Service General Hospital, Taipei, TaiwanTri-Service General Hospital, Taipei, TaiwanTransformation of a poorly differentiated squamous cell carcinoma (SCC) of the esophagus into a ''carcinosarcoma'' of the pleura and lung has never been reported and its histogenetic origin is still debated. A 48-year-old man was admitted due to progressive dysphagia and a weight loss of 5 kilograms within 2 months. Upper gastrointestinal panendoscopic biopsy revealed poorly differentiated SCC of thoracic esophagus, upper third, T4N1 M1a, stage IVa. He received concurrent chemoradiotherapy (CCRT). About 9 months later, rapid progression of lung metastases and pleural effusion were found. According to the histopathological and immunohistochemical stain results, carcinosarcoma was diagnosed. Palliative therapy was given and the patient eventually died of the disease 9 months after SCC of the thoracic esophagus was diagnosed and one month after carcinosarcoma of the pleura and lung were confirmed.http://www.sciencedirect.com/science/article/pii/S1658387610500578 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chien-Wen Chen Kuan-Yu Chen Chin-Jung Lin Wann-Cherng Perng Jia-Hong Chen |
spellingShingle |
Chien-Wen Chen Kuan-Yu Chen Chin-Jung Lin Wann-Cherng Perng Jia-Hong Chen Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus Hematology/Oncology and Stem Cell Therapy |
author_facet |
Chien-Wen Chen Kuan-Yu Chen Chin-Jung Lin Wann-Cherng Perng Jia-Hong Chen |
author_sort |
Chien-Wen Chen |
title |
Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus |
title_short |
Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus |
title_full |
Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus |
title_fullStr |
Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus |
title_full_unstemmed |
Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus |
title_sort |
carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus |
publisher |
Elsevier |
series |
Hematology/Oncology and Stem Cell Therapy |
issn |
1658-3876 |
publishDate |
2010-01-01 |
description |
Transformation of a poorly differentiated squamous cell carcinoma (SCC) of the esophagus into a ''carcinosarcoma'' of the pleura and lung has never been reported and its histogenetic origin is still debated. A 48-year-old man was admitted due to progressive dysphagia and a weight loss of 5 kilograms within 2 months. Upper gastrointestinal panendoscopic biopsy revealed poorly differentiated SCC of thoracic esophagus, upper third, T4N1 M1a, stage IVa. He received concurrent chemoradiotherapy (CCRT). About 9 months later, rapid progression of lung metastases and pleural effusion were found. According to the histopathological and immunohistochemical stain results, carcinosarcoma was diagnosed. Palliative therapy was given and the patient eventually died of the disease 9 months after SCC of the thoracic esophagus was diagnosed and one month after carcinosarcoma of the pleura and lung were confirmed. |
url |
http://www.sciencedirect.com/science/article/pii/S1658387610500578 |
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