Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs
<p>Abstract</p> <p>Current guidelines recommend the use of inhaled corticosteroids (ICS) for suppression of airway inflammation in patients with asthma. Although it is well known that ICS cause dose-related adrenocortical suppression, it is less known that they can lead to iatrogen...
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2012-08-01
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doaj-b67c2bab978543f0820cc03876bc2e932020-11-25T02:16:05ZengPAGEPress PublicationsMultidisciplinary Respiratory Medicine2049-69582012-08-01712610.1186/2049-6958-7-26Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugsCelik OzlemNiyazoglu MutluSoylu HikmetKadioglu Pinar<p>Abstract</p> <p>Current guidelines recommend the use of inhaled corticosteroids (ICS) for suppression of airway inflammation in patients with asthma. Although it is well known that ICS cause dose-related adrenocortical suppression, it is less known that they can lead to iatrogenic Cushing’s syndrome (CS). Fluticasone propionate (FP) is an ICS more potent than beclomethasone and budesonide. FP is metabolized as mediated by cytochrome P450 3A4 in the liver and the gut. Systemic bioactivity of FP can increase with the use of drugs that affect the cytochrome P450. Herein, we report the rapid development of iatrogenic CS in a patient receiving paroxetine and mirtazepine for 12 weeks in addition to inhaled FP.</p> http://www.mrmjournal.com/content/7/1/26Cushing’s syndromeFluticasone propionateMirtazepineParoxetine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Celik Ozlem Niyazoglu Mutlu Soylu Hikmet Kadioglu Pinar |
spellingShingle |
Celik Ozlem Niyazoglu Mutlu Soylu Hikmet Kadioglu Pinar Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs Multidisciplinary Respiratory Medicine Cushing’s syndrome Fluticasone propionate Mirtazepine Paroxetine |
author_facet |
Celik Ozlem Niyazoglu Mutlu Soylu Hikmet Kadioglu Pinar |
author_sort |
Celik Ozlem |
title |
Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs |
title_short |
Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs |
title_full |
Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs |
title_fullStr |
Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs |
title_full_unstemmed |
Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs |
title_sort |
iatrogenic cushing’s syndrome with inhaled steroid plus antidepressant drugs |
publisher |
PAGEPress Publications |
series |
Multidisciplinary Respiratory Medicine |
issn |
2049-6958 |
publishDate |
2012-08-01 |
description |
<p>Abstract</p> <p>Current guidelines recommend the use of inhaled corticosteroids (ICS) for suppression of airway inflammation in patients with asthma. Although it is well known that ICS cause dose-related adrenocortical suppression, it is less known that they can lead to iatrogenic Cushing’s syndrome (CS). Fluticasone propionate (FP) is an ICS more potent than beclomethasone and budesonide. FP is metabolized as mediated by cytochrome P450 3A4 in the liver and the gut. Systemic bioactivity of FP can increase with the use of drugs that affect the cytochrome P450. Herein, we report the rapid development of iatrogenic CS in a patient receiving paroxetine and mirtazepine for 12 weeks in addition to inhaled FP.</p> |
topic |
Cushing’s syndrome Fluticasone propionate Mirtazepine Paroxetine |
url |
http://www.mrmjournal.com/content/7/1/26 |
work_keys_str_mv |
AT celikozlem iatrogeniccushingssyndromewithinhaledsteroidplusantidepressantdrugs AT niyazoglumutlu iatrogeniccushingssyndromewithinhaledsteroidplusantidepressantdrugs AT soyluhikmet iatrogeniccushingssyndromewithinhaledsteroidplusantidepressantdrugs AT kadioglupinar iatrogeniccushingssyndromewithinhaledsteroidplusantidepressantdrugs |
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1724892927424987136 |