The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI)....
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doaj-b686adc131ae471c8612715cc7135e8c2020-11-24T21:40:27ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/285491285491The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo PopulationMónica Vázquez-Del Mercado0Milton-Omar Guzmán-Ornelas1Fernanda-Isadora Corona Meraz2Clara-Patricia Ríos-Ibarra3Eduardo-Alejandro Reyes-Serratos4Jorge Castro-Albarran5Sandra-Luz Ruíz-Quezada6Rosa-Elena Navarro-Hernández7Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, MexicoInstituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, MexicoCentro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, MexicoTecnológico de Monterrey, Campus Guadalajara, Avenida General Ramón Corona No. 2514, Colonia Nuevo México, 45201 Zapopan, JAL, MexicoTecnológico de Monterrey, Campus Guadalajara, Avenida General Ramón Corona No. 2514, Colonia Nuevo México, 45201 Zapopan, JAL, MexicoUDG-CA-701, Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, MexicoUDG-CA-701, Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes (GIIEE), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, MexicoInstituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, MexicoThe aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI). Body dimensions and distribution of body fat were measured. The HOMA-IR and adiposity indexes were calculated. Adipokines and metabolic profile quantification were performed by ELISA and routine methods. Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis. A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed. Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly− phenotype. Subjects with PPARG2 Ala− phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala). We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased.http://dx.doi.org/10.1155/2015/285491 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mónica Vázquez-Del Mercado Milton-Omar Guzmán-Ornelas Fernanda-Isadora Corona Meraz Clara-Patricia Ríos-Ibarra Eduardo-Alejandro Reyes-Serratos Jorge Castro-Albarran Sandra-Luz Ruíz-Quezada Rosa-Elena Navarro-Hernández |
spellingShingle |
Mónica Vázquez-Del Mercado Milton-Omar Guzmán-Ornelas Fernanda-Isadora Corona Meraz Clara-Patricia Ríos-Ibarra Eduardo-Alejandro Reyes-Serratos Jorge Castro-Albarran Sandra-Luz Ruíz-Quezada Rosa-Elena Navarro-Hernández The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population BioMed Research International |
author_facet |
Mónica Vázquez-Del Mercado Milton-Omar Guzmán-Ornelas Fernanda-Isadora Corona Meraz Clara-Patricia Ríos-Ibarra Eduardo-Alejandro Reyes-Serratos Jorge Castro-Albarran Sandra-Luz Ruíz-Quezada Rosa-Elena Navarro-Hernández |
author_sort |
Mónica Vázquez-Del Mercado |
title |
The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population |
title_short |
The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population |
title_full |
The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population |
title_fullStr |
The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population |
title_full_unstemmed |
The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population |
title_sort |
482ser of ppargc1a and 12pro of pparg2 alleles are associated with reduction of metabolic risk factors even obesity in a mexican-mestizo population |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI). Body dimensions and distribution of body fat were measured. The HOMA-IR and adiposity indexes were calculated. Adipokines and metabolic profile quantification were performed by ELISA and routine methods. Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis. A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed. Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly− phenotype. Subjects with PPARG2 Ala− phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala). We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased. |
url |
http://dx.doi.org/10.1155/2015/285491 |
work_keys_str_mv |
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