Polypyrimidine tract-binding proteins are essential for B cell development

Polypyrimidine tract-binding proteins are essential for B cell development

Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of bot...

Full description

Bibliographic Details
Main Authors: Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
B cell development
RNA-binding proteins
alternative splicing
cell cycle
Online Access:https://elifesciences.org/articles/53557

Internet

https://elifesciences.org/articles/53557

Similar Items