Polypyrimidine tract-binding proteins are essential for B cell development
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of bot...
Main Authors: | Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-02-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/53557 |
Similar Items
-
New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein
by: Maria Grazia Romanelli, et al.
Published: (2013-11-01) -
The role of polypyrimidine tract-binding proteins and other hnRNP proteins in plant splicing regulation
by: Andreas eWachter, et al.
Published: (2012-05-01) -
The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition
by: Holly T. Reardon, et al.
Published: (2011-12-01) -
Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)
by: Amar Joshi, et al.
Published: (2014-03-01) -
An extensive program of periodic alternative splicing linked to cell cycle progression
by: Daniel Dominguez, et al.
Published: (2016-03-01)