<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial
Background: The aim of this study was to investigate the efficacy of <i>Lactobacillus rhamnosus </i>ATCC 53103 together with the maternal diet avoidance of cow’s milk in treating infantile colic. Methods:<b> </b>Forty-five<b> </b>colicky breastfed infants were con...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/12/6/1693 |
id |
doaj-b6b0c1e0e6804f4b9cb0ed4e4365c6a7 |
---|---|
record_format |
Article |
spelling |
doaj-b6b0c1e0e6804f4b9cb0ed4e4365c6a72020-11-25T03:19:51ZengMDPI AGNutrients2072-66432020-06-01121693169310.3390/nu12061693<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled TrialFrancesco Savino0Paola Montanari1Ilaria Galliano2Valentina Daprà3Massimiliano Bergallo4Department of Pediatrics, S.S.D. Subintensive Neonatal Care, Children Hospital “Regina Margherita”, A.U.O. Città della Salute e della Scienza di Torino, 10126 Torino, ItalyDipartimento delle Scienze di Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Scuola di Medicina, 10126 Torino, ItalyDipartimento delle Scienze di Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Scuola di Medicina, 10126 Torino, ItalyDipartimento delle Scienze di Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Scuola di Medicina, 10126 Torino, ItalyDipartimento delle Scienze di Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Scuola di Medicina, 10126 Torino, ItalyBackground: The aim of this study was to investigate the efficacy of <i>Lactobacillus rhamnosus </i>ATCC 53103 together with the maternal diet avoidance of cow’s milk in treating infantile colic. Methods:<b> </b>Forty-five<b> </b>colicky breastfed infants were consecutively randomized to receive <i>L. rhamnosus</i> for 28 days at a dosage of 5 × 10<sup>9</sup> cfu per day or placebo. Faecal samples were collected from each subject before starting supplementation and at the end of the study period and were immediately analysed. Faecal calprotectin was detected via a quantitative assay. The total bacterial load and selected bacterial species were evaluated using real-time TaqMan PCR. Results:<b> </b>After supplementation for 28 days with <i>Lactobacillus rhamnosus</i> ATCC 53103, median full-force daily crying was reduced (104 versus 242 min, <i>p</i> < 0.001) and the values of faecal calprotectin decreased significantly (<i>p = </i>0.026). Furthermore, the probiotic increased the abundance of <i>Lactobacillus</i> (<i>p</i> = 0.048) and total bacteria (<i>p</i> = 0.040); all these effects were not observed in the placebo group. Conclusion: Infants treated with <i>Lactobacillus rhamnosus ATCC 53103</i> for 28 days, in association with the elimination of cow’s milk from the maternal diet, presented some interesting features related to the effect of this probiotic treatment: reductions in crying time and faecal calprotectin, with increased total bacteria and <i>Lactobacillus.</i> To validate these results, a double-blind, placebo-controlled trial on a larger cohort is required.https://www.mdpi.com/2072-6643/12/6/1693<i>Lactobacillus rhamnosus</i> (ATCC 53103)infantile colic<i>Lactobacillus</i>total bacteriafaecal calprotectin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesco Savino Paola Montanari Ilaria Galliano Valentina Daprà Massimiliano Bergallo |
spellingShingle |
Francesco Savino Paola Montanari Ilaria Galliano Valentina Daprà Massimiliano Bergallo <i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial Nutrients <i>Lactobacillus rhamnosus</i> (ATCC 53103) infantile colic <i>Lactobacillus</i> total bacteria faecal calprotectin |
author_facet |
Francesco Savino Paola Montanari Ilaria Galliano Valentina Daprà Massimiliano Bergallo |
author_sort |
Francesco Savino |
title |
<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial |
title_short |
<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial |
title_full |
<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial |
title_fullStr |
<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial |
title_full_unstemmed |
<i>Lactobacillus rhamnosus GG </i>(ATCC 53103)<i> </i>for the Management of Infantile Colic: A Randomized Controlled Trial |
title_sort |
<i>lactobacillus rhamnosus gg </i>(atcc 53103)<i> </i>for the management of infantile colic: a randomized controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-06-01 |
description |
Background: The aim of this study was to investigate the efficacy of <i>Lactobacillus rhamnosus </i>ATCC 53103 together with the maternal diet avoidance of cow’s milk in treating infantile colic. Methods:<b> </b>Forty-five<b> </b>colicky breastfed infants were consecutively randomized to receive <i>L. rhamnosus</i> for 28 days at a dosage of 5 × 10<sup>9</sup> cfu per day or placebo. Faecal samples were collected from each subject before starting supplementation and at the end of the study period and were immediately analysed. Faecal calprotectin was detected via a quantitative assay. The total bacterial load and selected bacterial species were evaluated using real-time TaqMan PCR. Results:<b> </b>After supplementation for 28 days with <i>Lactobacillus rhamnosus</i> ATCC 53103, median full-force daily crying was reduced (104 versus 242 min, <i>p</i> < 0.001) and the values of faecal calprotectin decreased significantly (<i>p = </i>0.026). Furthermore, the probiotic increased the abundance of <i>Lactobacillus</i> (<i>p</i> = 0.048) and total bacteria (<i>p</i> = 0.040); all these effects were not observed in the placebo group. Conclusion: Infants treated with <i>Lactobacillus rhamnosus ATCC 53103</i> for 28 days, in association with the elimination of cow’s milk from the maternal diet, presented some interesting features related to the effect of this probiotic treatment: reductions in crying time and faecal calprotectin, with increased total bacteria and <i>Lactobacillus.</i> To validate these results, a double-blind, placebo-controlled trial on a larger cohort is required. |
topic |
<i>Lactobacillus rhamnosus</i> (ATCC 53103) infantile colic <i>Lactobacillus</i> total bacteria faecal calprotectin |
url |
https://www.mdpi.com/2072-6643/12/6/1693 |
work_keys_str_mv |
AT francescosavino ilactobacillusrhamnosusggiatcc53103iiforthemanagementofinfantilecolicarandomizedcontrolledtrial AT paolamontanari ilactobacillusrhamnosusggiatcc53103iiforthemanagementofinfantilecolicarandomizedcontrolledtrial AT ilariagalliano ilactobacillusrhamnosusggiatcc53103iiforthemanagementofinfantilecolicarandomizedcontrolledtrial AT valentinadapra ilactobacillusrhamnosusggiatcc53103iiforthemanagementofinfantilecolicarandomizedcontrolledtrial AT massimilianobergallo ilactobacillusrhamnosusggiatcc53103iiforthemanagementofinfantilecolicarandomizedcontrolledtrial |
_version_ |
1724620596284751872 |