PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

Repair of myelin damage in the adult CNS requires oligodendrocyte progenitor (OP) proliferation and subsequent differentiation into remyelinating oligodendrocytes. Platelet-derived growth factor (PDGF) and fibroblast growth factor-2 (FGF2) have been predicted to act individually and/or cooperatively...

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Bibliographic Details
Main Authors: Joshua C. Murtie, Yong-Xing Zhou, Tuan Q. Le, Adam C. Vana, Regina C. Armstrong
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Demyelinating disease
Multiple sclerosis
Remyelination
Demyelination
Oligodendrocyte
Progenitor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002918

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