Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy

Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as “windows into the brain” can predict incidence of Alzheimer’s Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translati...

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Main Authors:	Pete Heinzelman, Tina Bilousova, Jesus Campagna, Varghese John
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	International Journal of Alzheimer's Disease
Online Access:	http://dx.doi.org/10.1155/2016/8053139

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spelling	doaj-b6c63f6cf9da4a69929c0f02e66889ca2020-11-24T23:04:19ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-80242090-02522016-01-01201610.1155/2016/80531398053139Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and TherapyPete Heinzelman0Tina Bilousova1Jesus Campagna2Varghese John3Drug Discovery Laboratory, Department of Neurology, Easton Center for Alzheimer’s Disease Research, University of California, Los Angeles, CA 90095, USADrug Discovery Laboratory, Department of Neurology, Easton Center for Alzheimer’s Disease Research, University of California, Los Angeles, CA 90095, USADrug Discovery Laboratory, Department of Neurology, Easton Center for Alzheimer’s Disease Research, University of California, Los Angeles, CA 90095, USADrug Discovery Laboratory, Department of Neurology, Easton Center for Alzheimer’s Disease Research, University of California, Los Angeles, CA 90095, USADiagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as “windows into the brain” can predict incidence of Alzheimer’s Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translational impact by revealing mechanisms of AD pathology; such knowledge could enlighten new drug targets and lead to new therapeutic approaches. The potential to establish three-dimensional nsEV analysis methods that characterize highly purified bloodborne nsEV populations in method of enrichment, cell type origin, and protein or RNA abundance dimensions could bring this promise to bear by yielding nsEV “omics” datasets that uncover new AD biomarkers and enable AD therapeutic development. In this review we provide a survey of both the current status of and new developments on the horizon in the field of neuronal nsEV analysis. This survey is supplemented by a discussion of the potential to translate such neuronal nsEV analyses to AD clinical diagnostic applications and drug development.http://dx.doi.org/10.1155/2016/8053139
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pete Heinzelman Tina Bilousova Jesus Campagna Varghese John
spellingShingle	Pete Heinzelman Tina Bilousova Jesus Campagna Varghese John Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy International Journal of Alzheimer's Disease
author_facet	Pete Heinzelman Tina Bilousova Jesus Campagna Varghese John
author_sort	Pete Heinzelman
title	Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy
title_short	Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy
title_full	Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy
title_fullStr	Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy
title_full_unstemmed	Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy
title_sort	nanoscale extracellular vesicle analysis in alzheimer’s disease diagnosis and therapy
publisher	Hindawi Limited
series	International Journal of Alzheimer's Disease
issn	2090-8024 2090-0252
publishDate	2016-01-01
description	Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as “windows into the brain” can predict incidence of Alzheimer’s Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translational impact by revealing mechanisms of AD pathology; such knowledge could enlighten new drug targets and lead to new therapeutic approaches. The potential to establish three-dimensional nsEV analysis methods that characterize highly purified bloodborne nsEV populations in method of enrichment, cell type origin, and protein or RNA abundance dimensions could bring this promise to bear by yielding nsEV “omics” datasets that uncover new AD biomarkers and enable AD therapeutic development. In this review we provide a survey of both the current status of and new developments on the horizon in the field of neuronal nsEV analysis. This survey is supplemented by a discussion of the potential to translate such neuronal nsEV analyses to AD clinical diagnostic applications and drug development.
url	http://dx.doi.org/10.1155/2016/8053139
work_keys_str_mv	AT peteheinzelman nanoscaleextracellularvesicleanalysisinalzheimersdiseasediagnosisandtherapy AT tinabilousova nanoscaleextracellularvesicleanalysisinalzheimersdiseasediagnosisandtherapy AT jesuscampagna nanoscaleextracellularvesicleanalysisinalzheimersdiseasediagnosisandtherapy AT varghesejohn nanoscaleextracellularvesicleanalysisinalzheimersdiseasediagnosisandtherapy
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Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy

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