The change in function of Th1 and Th2-lymphocytes and cytokine profile at chronic intoxication of ethanol
In experiments in non-inbred rats, it has been established that chronic intoxication of ethanol (30 days, total dose – 6.0 LD50) essentially reduces concentration of cytokines IFNγ, IL-2, IL-4, IL-10 in blood, increases concentration of IL-6, reduces an interrelation IFNγ/IL-4 in comparison with the...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Limited liability company «Science and Innovations» (Saratov)
2012-09-01
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Series: | Russian Open Medical Journal |
Subjects: | |
Online Access: | http://www.romj.org/node/30 |
Summary: | In experiments in non-inbred rats, it has been established that chronic intoxication of ethanol (30 days, total dose – 6.0 LD50) essentially reduces concentration of cytokines IFNγ, IL-2, IL-4, IL-10 in blood, increases concentration of IL-6, reduces an interrelation IFNγ/IL-4 in comparison with the control, suppresses of immune responses, which displays the greater lesion of Th1-cells in comparison with Th2-lymphosytes. |
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ISSN: | 2304-3415 |