Variable Baseline Papio cynocephalus Endogenous Retrovirus (PcEV) Expression Is Upregulated in Acutely SIV-Infected Macaques and Correlated to STAT1 Expression in the Spleen

Variable Baseline Papio cynocephalus Endogenous Retrovirus (PcEV) Expression Is Upregulated in Acutely SIV-Infected Macaques and Correlated to STAT1 Expression in the Spleen

Retroviral replication leaves a DNA copy in the host cell chromosome, which over millions of years of infection of germline cells has led to 5% of the human genome sequence being comprised of endogenous retroviruses (ERVs), distributed throughout an estimated 100,000 loci. Over time these loci have...

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Bibliographic Details
Main Authors: Emmanuel Atangana Maze, Claire Ham, Jack Kelly, Lindsay Ussher, Neil Almond, Greg J. Towers, Neil Berry, Robert Belshaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
endogenous retrovirus
STAT1
macaque
PcEV
SIV
RNA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00901/full

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