Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in acti...
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doaj-b6d0453d4e304de29b505cc28cac61c02020-11-25T00:39:39ZengMDPI AGNutrients2072-66432018-10-011010155510.3390/nu10101555nu10101555Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly PeopleCarla Busquets-Cortés0Xavier Capó1Maria del Mar Bibiloni2Miquel Martorell3Miguel D. Ferrer4Emma Argelich5Cristina Bouzas6Sandra Carreres7Josep A. Tur8Antoni Pons9Antoni Sureda10Research Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainDepartamento de Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, 4070386 Concepción, ChileResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress & Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, SpainRegular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate and inactive elderly. In total, 127 healthy men and women >55 years old participated in the study and were classified according on their level of declared physical activity. A more active lifestyle was accompanied by lower weight, fat mass and body mass index when compared to a more sedentary life-style. Active participants exhibited lower circulating PBMCs than inactive peers. Participants who reported higher levels of exercise had increased antioxidant protein levels when compared to more sedentary partakers. Carbonylated protein levels exhibited similar behavior, accompanied by a significant raise in expression of cytochrome c oxidase subunit IV in PBMCs. No significant changes were found in the activities of antioxidant enzymes and in the expression of structural (MitND5) and mitochondrial dynamic-related (PGC1α and Mitofusins1/2.) proteins. Active lifestyle and daily activities exert beneficial effects on body composition and it enhances the antioxidant defenses and oxidative metabolism capabilities in PBMCs from healthy elderly.http://www.mdpi.com/2072-6643/10/10/1555active lifestyleantioxidantsdaily habitselderlyhealthy agingmitochondriaPBMCsROS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carla Busquets-Cortés Xavier Capó Maria del Mar Bibiloni Miquel Martorell Miguel D. Ferrer Emma Argelich Cristina Bouzas Sandra Carreres Josep A. Tur Antoni Pons Antoni Sureda |
spellingShingle |
Carla Busquets-Cortés Xavier Capó Maria del Mar Bibiloni Miquel Martorell Miguel D. Ferrer Emma Argelich Cristina Bouzas Sandra Carreres Josep A. Tur Antoni Pons Antoni Sureda Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People Nutrients active lifestyle antioxidants daily habits elderly healthy aging mitochondria PBMCs ROS |
author_facet |
Carla Busquets-Cortés Xavier Capó Maria del Mar Bibiloni Miquel Martorell Miguel D. Ferrer Emma Argelich Cristina Bouzas Sandra Carreres Josep A. Tur Antoni Pons Antoni Sureda |
author_sort |
Carla Busquets-Cortés |
title |
Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People |
title_short |
Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People |
title_full |
Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People |
title_fullStr |
Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People |
title_full_unstemmed |
Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People |
title_sort |
peripheral blood mononuclear cells antioxidant adaptations to regular physical activity in elderly people |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-10-01 |
description |
Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate and inactive elderly. In total, 127 healthy men and women >55 years old participated in the study and were classified according on their level of declared physical activity. A more active lifestyle was accompanied by lower weight, fat mass and body mass index when compared to a more sedentary life-style. Active participants exhibited lower circulating PBMCs than inactive peers. Participants who reported higher levels of exercise had increased antioxidant protein levels when compared to more sedentary partakers. Carbonylated protein levels exhibited similar behavior, accompanied by a significant raise in expression of cytochrome c oxidase subunit IV in PBMCs. No significant changes were found in the activities of antioxidant enzymes and in the expression of structural (MitND5) and mitochondrial dynamic-related (PGC1α and Mitofusins1/2.) proteins. Active lifestyle and daily activities exert beneficial effects on body composition and it enhances the antioxidant defenses and oxidative metabolism capabilities in PBMCs from healthy elderly. |
topic |
active lifestyle antioxidants daily habits elderly healthy aging mitochondria PBMCs ROS |
url |
http://www.mdpi.com/2072-6643/10/10/1555 |
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