The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps.
Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and N-acetyl-galactosamine (GalNAc) that mediates adherence and is required for full virulence...
Main Authors: | Mark J Lee, Hong Liu, Bridget M Barker, Brendan D Snarr, Fabrice N Gravelat, Qusai Al Abdallah, Christina Gavino, Shane R Baistrocchi, Hanna Ostapska, Tianli Xiao, Benjamin Ralph, Norma V Solis, Mélanie Lehoux, Stefanie D Baptista, Arsa Thammahong, Robert P Cerone, Susan G W Kaminskyj, Marie-Christine Guiot, Jean-Paul Latgé, Thierry Fontaine, Donald C Vinh, Scott G Filler, Donald C Sheppard |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-10-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4619649?pdf=render |
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