Oxidative Stress in Chagas Disease
There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress induced injuries that may contribute to disease progression. Trypanosoma cruzi invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of...
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2009-01-01
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Series: | Interdisciplinary Perspectives on Infectious Diseases |
Online Access: | http://dx.doi.org/10.1155/2009/190354 |
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doaj-b6e045ac7486487e9047b7a38db0b25b2020-11-24T23:04:17ZengHindawi LimitedInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982009-01-01200910.1155/2009/190354190354Oxidative Stress in Chagas DiseaseShivali Gupta0Jian-Jun Wen1Nisha Jain Garg2Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAThere is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress induced injuries that may contribute to disease progression. Trypanosoma cruzi invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) during acute infection. Mitochondria are proposed to be the major source of ROS in chronic chagasic hearts. However, it has not been established yet, whether mitochondrial dysfunction is a causative factor in chagasic cardiomyopathy or a consequence of other pathological events. A better understanding of oxidative stress in relation to cardiac tissue damage would be useful in the evaluation of its true role in the pathogenesis of Chagas disease and other heart diseases. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, and its role in sustaining oxidative stress in myocardium.http://dx.doi.org/10.1155/2009/190354 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shivali Gupta Jian-Jun Wen Nisha Jain Garg |
spellingShingle |
Shivali Gupta Jian-Jun Wen Nisha Jain Garg Oxidative Stress in Chagas Disease Interdisciplinary Perspectives on Infectious Diseases |
author_facet |
Shivali Gupta Jian-Jun Wen Nisha Jain Garg |
author_sort |
Shivali Gupta |
title |
Oxidative Stress in Chagas Disease |
title_short |
Oxidative Stress in Chagas Disease |
title_full |
Oxidative Stress in Chagas Disease |
title_fullStr |
Oxidative Stress in Chagas Disease |
title_full_unstemmed |
Oxidative Stress in Chagas Disease |
title_sort |
oxidative stress in chagas disease |
publisher |
Hindawi Limited |
series |
Interdisciplinary Perspectives on Infectious Diseases |
issn |
1687-708X 1687-7098 |
publishDate |
2009-01-01 |
description |
There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress induced injuries that may contribute to disease progression. Trypanosoma cruzi invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) during acute infection. Mitochondria are proposed to be the major source of ROS in chronic chagasic hearts. However, it has not been established yet, whether mitochondrial dysfunction is a causative factor in chagasic cardiomyopathy or a consequence of other pathological events. A better understanding of oxidative stress in relation to cardiac tissue damage would be useful in the evaluation of its true role in the pathogenesis of Chagas disease and other heart diseases. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, and its role in sustaining oxidative stress in myocardium. |
url |
http://dx.doi.org/10.1155/2009/190354 |
work_keys_str_mv |
AT shivaligupta oxidativestressinchagasdisease AT jianjunwen oxidativestressinchagasdisease AT nishajaingarg oxidativestressinchagasdisease |
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1725631473498718208 |