Added value of diffusion-weighted MRI in assessment of pleural lesions
Abstract Background There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water molecules diffusivity. The aim of this study was t...
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doaj-b6e8612101b5467b88751553615f527f2021-08-01T11:29:03ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622021-07-015211910.1186/s43055-021-00557-3Added value of diffusion-weighted MRI in assessment of pleural lesionsYoussriah Yahia Sabri0Ikram Hamed Mahmoud1Lamis Tarek El-Gendy2Mohamed Raafat Abd El-Mageed3Sally Fouad Tadros4Faculty of Medicine, Cairo University, Kasr Al-Ainy Faculty of MedicineNational Cancer InstituteNational Institute of Diabetes and EndocrinologyFaculty of Medicine, Cairo University, Kasr Al-Ainy Faculty of MedicineFaculty of Medicine, Cairo University, Kasr Al-Ainy Faculty of MedicineAbstract Background There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water molecules diffusivity. The aim of this study was to evaluate the diagnostic value of DWI-MRI in detection and characterization of pleural diseases and its capability in differentiating benign from malignant pleural lesions. Results Conventional MRI was able to discriminate benign from malignant lesions by using morphological features (contour and thickness) with sensitivity 89.29%, specificity 76%, positive predictive value 89%, negative predictive value 76.92%, and accuracy 85.37%. ADC value as a quantitative parameter of DWI found that ADC values of malignant pleural diseases were significantly lower than that of benign lesions (P < 0.001). Hence, we discovered that using ADC mean value of 1.68 × 10-3 mm2/s as a cutoff value can differentiate malignant from benign pleural diseases with sensitivity 89.3%, specificity 100%, positive predictive value 100%, negative predictive value 81.2%, and accuracy 92.68% (P < 0.001). Conclusion Although DWI-MRI is unable to differentiate between malignant and benign pleural effusion, its combined morphological and functional information provide valid non-invasive method to accurately characterize pleural soft tissue diseases differentiating benign from malignant lesions with higher specificity and accuracy than conventional MRI.https://doi.org/10.1186/s43055-021-00557-3DWIPleural lesionsMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Youssriah Yahia Sabri Ikram Hamed Mahmoud Lamis Tarek El-Gendy Mohamed Raafat Abd El-Mageed Sally Fouad Tadros |
spellingShingle |
Youssriah Yahia Sabri Ikram Hamed Mahmoud Lamis Tarek El-Gendy Mohamed Raafat Abd El-Mageed Sally Fouad Tadros Added value of diffusion-weighted MRI in assessment of pleural lesions The Egyptian Journal of Radiology and Nuclear Medicine DWI Pleural lesions MRI |
author_facet |
Youssriah Yahia Sabri Ikram Hamed Mahmoud Lamis Tarek El-Gendy Mohamed Raafat Abd El-Mageed Sally Fouad Tadros |
author_sort |
Youssriah Yahia Sabri |
title |
Added value of diffusion-weighted MRI in assessment of pleural lesions |
title_short |
Added value of diffusion-weighted MRI in assessment of pleural lesions |
title_full |
Added value of diffusion-weighted MRI in assessment of pleural lesions |
title_fullStr |
Added value of diffusion-weighted MRI in assessment of pleural lesions |
title_full_unstemmed |
Added value of diffusion-weighted MRI in assessment of pleural lesions |
title_sort |
added value of diffusion-weighted mri in assessment of pleural lesions |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Radiology and Nuclear Medicine |
issn |
2090-4762 |
publishDate |
2021-07-01 |
description |
Abstract Background There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water molecules diffusivity. The aim of this study was to evaluate the diagnostic value of DWI-MRI in detection and characterization of pleural diseases and its capability in differentiating benign from malignant pleural lesions. Results Conventional MRI was able to discriminate benign from malignant lesions by using morphological features (contour and thickness) with sensitivity 89.29%, specificity 76%, positive predictive value 89%, negative predictive value 76.92%, and accuracy 85.37%. ADC value as a quantitative parameter of DWI found that ADC values of malignant pleural diseases were significantly lower than that of benign lesions (P < 0.001). Hence, we discovered that using ADC mean value of 1.68 × 10-3 mm2/s as a cutoff value can differentiate malignant from benign pleural diseases with sensitivity 89.3%, specificity 100%, positive predictive value 100%, negative predictive value 81.2%, and accuracy 92.68% (P < 0.001). Conclusion Although DWI-MRI is unable to differentiate between malignant and benign pleural effusion, its combined morphological and functional information provide valid non-invasive method to accurately characterize pleural soft tissue diseases differentiating benign from malignant lesions with higher specificity and accuracy than conventional MRI. |
topic |
DWI Pleural lesions MRI |
url |
https://doi.org/10.1186/s43055-021-00557-3 |
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