Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma

Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma

Abstract Background Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and activates anti-tumor immunity. However, TLR3 signaling can also harbor pro-tumorigenic consequences. Therefore, we examined the status of TLR3 in cholangiocarcinoma (CCA) cases to...

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Bibliographic Details
Main Authors: Thanpisit Lomphithak, Swati Choksi, Apiwat Mutirangura, Rutaiwan Tohtong, Tewin Tencomnao, Hajime Usubuchi, Michiaki Unno, Hironobu Sasano, Siriporn Jitkaew
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cell Communication and Signaling
Subjects:
Toll-like receptor 3
Smac mimetic
Receptor-interacting protein kinase 1 (RIPK1)
Necroptosis
Invasion
Cholangiocarcinoma
Online Access:http://link.springer.com/article/10.1186/s12964-020-00661-3

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