Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.
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2018-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03880-y |
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doaj-b6e9e26c80024b1e84795b448f5f9b652021-05-11T10:07:42ZengNature Publishing GroupNature Communications2041-17232018-05-019111110.1038/s41467-018-03880-yChemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in miceRaffaella Rossin0Ron M. Versteegen1Jeremy Wu2Alisher Khasanov3Hans J. Wessels4Erik J. Steenbergen5Wolter ten Hoeve6Henk M. Janssen7Arthur H. A. M. van Onzen8Peter J. Hudson9Marc S. Robillard10Tagworks PharmaceuticalsSyMO-Chem B.V.Avipep Pty LtdLevena Biopharma, 4955 Directors PlaceRadboud Proteomics Centre, Department of Laboratory Medicine, Radboud University Medical CenterDepartment of Pathology, Radboud University Medical CenterSyncom B.V.SyMO-Chem B.V.Tagworks PharmaceuticalsAvipep Pty LtdTagworks PharmaceuticalsCurrent antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.https://doi.org/10.1038/s41467-018-03880-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raffaella Rossin Ron M. Versteegen Jeremy Wu Alisher Khasanov Hans J. Wessels Erik J. Steenbergen Wolter ten Hoeve Henk M. Janssen Arthur H. A. M. van Onzen Peter J. Hudson Marc S. Robillard |
spellingShingle |
Raffaella Rossin Ron M. Versteegen Jeremy Wu Alisher Khasanov Hans J. Wessels Erik J. Steenbergen Wolter ten Hoeve Henk M. Janssen Arthur H. A. M. van Onzen Peter J. Hudson Marc S. Robillard Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice Nature Communications |
author_facet |
Raffaella Rossin Ron M. Versteegen Jeremy Wu Alisher Khasanov Hans J. Wessels Erik J. Steenbergen Wolter ten Hoeve Henk M. Janssen Arthur H. A. M. van Onzen Peter J. Hudson Marc S. Robillard |
author_sort |
Raffaella Rossin |
title |
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice |
title_short |
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice |
title_full |
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice |
title_fullStr |
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice |
title_full_unstemmed |
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice |
title_sort |
chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-05-01 |
description |
Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger. |
url |
https://doi.org/10.1038/s41467-018-03880-y |
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