Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine
The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive b...
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University of Belgrade, University of Novi Sad
2012-01-01
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doaj-b6f072df9a2144128874a6add0560bf52020-11-24T21:37:08ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392012-01-01641152010.2298/ABS1201015NInvestigation of antibacterial activity of cinnamyl derivatives of arylpiperazineNovaković IrenaPenjišević JelenaŠukalović V.Andrić DeanaRoglić G.Kostić-Rajačić SlađanaThe derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.http://www.doiserbia.nb.rs/img/doi/0354-4664/2012/0354-46641201015N.pdfarylpiperazineantibacterial activityminimum inhibitory concentrationin vitro studies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Novaković Irena Penjišević Jelena Šukalović V. Andrić Deana Roglić G. Kostić-Rajačić Slađana |
spellingShingle |
Novaković Irena Penjišević Jelena Šukalović V. Andrić Deana Roglić G. Kostić-Rajačić Slađana Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine Archives of Biological Sciences arylpiperazine antibacterial activity minimum inhibitory concentration in vitro studies |
author_facet |
Novaković Irena Penjišević Jelena Šukalović V. Andrić Deana Roglić G. Kostić-Rajačić Slađana |
author_sort |
Novaković Irena |
title |
Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine |
title_short |
Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine |
title_full |
Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine |
title_fullStr |
Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine |
title_full_unstemmed |
Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine |
title_sort |
investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine |
publisher |
University of Belgrade, University of Novi Sad |
series |
Archives of Biological Sciences |
issn |
0354-4664 1821-4339 |
publishDate |
2012-01-01 |
description |
The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin. |
topic |
arylpiperazine antibacterial activity minimum inhibitory concentration in vitro studies |
url |
http://www.doiserbia.nb.rs/img/doi/0354-4664/2012/0354-46641201015N.pdf |
work_keys_str_mv |
AT novakovicirena investigationofantibacterialactivityofcinnamylderivativesofarylpiperazine AT penjisevicjelena investigationofantibacterialactivityofcinnamylderivativesofarylpiperazine AT sukalovicv investigationofantibacterialactivityofcinnamylderivativesofarylpiperazine AT andricdeana investigationofantibacterialactivityofcinnamylderivativesofarylpiperazine AT roglicg investigationofantibacterialactivityofcinnamylderivativesofarylpiperazine AT kosticrajacicslađana investigationofantibacterialactivityofcinnamylderivativesofarylpiperazine |
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