Atopic Dermatitis: Drug Delivery (Management) and Approaches (Strategies) in Perspective

• Main Author: Virendra N. Sehgal
• Format: Article
• Language: English
• Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2018-04-01
• Series: Annals of the National Academy of Medical Sciences (India)
• Subjects: atopic dermatitis; immunoglobulins e; cyclosporin; azathioprine; thymopentin; interferon-therapy
• Online Access: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1712790

Age-related cutaneous manifestations are definitive pointer to the diagnosis of atopic dermatitis, the confirmation of which is solicited by 3 major and 3 minor criteria. Its unpredictable course is punctuated by exacerbations and remissions. Several treatment options, namely: 1st, 2nd and 3rd line are in vogue ever since. The 1st line envisages general measures, 2nd encompasses topical applications, while the 3rd take into account drug therapy comprising, systemic Corticosteroids, Cyclosporin, Azathioprine, Thymopentin, Interferon–therapy, Topical Calcineurin inhibitors: Tacrolimus and Pimecrolimus. The mode of action, their dosages and adverse drug reaction (ADR), in particular, have been focused in this paper with special attention to refresh their drug delivery (management) approaches (strategies) in perspective. An endeavor to focus attention to emerging etio-pathogenesis, and its application in the contemporary context has also been made.