Role of non-coding-RNAs in response to environmental stressors and consequences on human health
Environmental risk factors, including physicochemical agents, noise and mental stress, have a considerable impact on human health. This environmental exposure may lead to epigenetic reprogramming, including changes in non-coding RNAs (ncRNAs) signatures, which can contribute to the pathophysiology s...
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2020-10-01
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Series: | Redox Biology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231720302482 |
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doaj-b718534840c4438485deee6e4db0b6ef2020-12-21T04:42:11ZengElsevierRedox Biology2213-23172020-10-0137101580Role of non-coding-RNAs in response to environmental stressors and consequences on human healthVerónica Miguel0Santiago Lamas1Cristina Espinosa-Diez2Programme of Physiological and Pathological Processes, Centro de Biología Molecular ''Severo Ochoa'' (CSIC-UAM), Madrid, SpainProgramme of Physiological and Pathological Processes, Centro de Biología Molecular ''Severo Ochoa'' (CSIC-UAM), Madrid, SpainPittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, PA, USA; Corresponding author.Environmental risk factors, including physicochemical agents, noise and mental stress, have a considerable impact on human health. This environmental exposure may lead to epigenetic reprogramming, including changes in non-coding RNAs (ncRNAs) signatures, which can contribute to the pathophysiology state. Oxidative stress is one of the results of this environmental disturbance by modifying cellular processes such as apoptosis, signal transduction cascades, and DNA repair mechanisms. In this review, we delineate environmental risk factors and their influence on (ncRNAs) in connection to disease. We focus on well-studied miRNAs and analyze the novel roles of long-non-coding-RNAs (lncRNAs). We discuss commonly regulated lncRNAs after exposure to different stressors, such as UV, heavy metals and pesticides among others, and the potential role of these lncRNA as exposure biomarkers, epigenetic regulators and potential therapeutic targets to diminish the deleterious secondary response to environmental agents.http://www.sciencedirect.com/science/article/pii/S2213231720302482 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Verónica Miguel Santiago Lamas Cristina Espinosa-Diez |
spellingShingle |
Verónica Miguel Santiago Lamas Cristina Espinosa-Diez Role of non-coding-RNAs in response to environmental stressors and consequences on human health Redox Biology |
author_facet |
Verónica Miguel Santiago Lamas Cristina Espinosa-Diez |
author_sort |
Verónica Miguel |
title |
Role of non-coding-RNAs in response to environmental stressors and consequences on human health |
title_short |
Role of non-coding-RNAs in response to environmental stressors and consequences on human health |
title_full |
Role of non-coding-RNAs in response to environmental stressors and consequences on human health |
title_fullStr |
Role of non-coding-RNAs in response to environmental stressors and consequences on human health |
title_full_unstemmed |
Role of non-coding-RNAs in response to environmental stressors and consequences on human health |
title_sort |
role of non-coding-rnas in response to environmental stressors and consequences on human health |
publisher |
Elsevier |
series |
Redox Biology |
issn |
2213-2317 |
publishDate |
2020-10-01 |
description |
Environmental risk factors, including physicochemical agents, noise and mental stress, have a considerable impact on human health. This environmental exposure may lead to epigenetic reprogramming, including changes in non-coding RNAs (ncRNAs) signatures, which can contribute to the pathophysiology state. Oxidative stress is one of the results of this environmental disturbance by modifying cellular processes such as apoptosis, signal transduction cascades, and DNA repair mechanisms. In this review, we delineate environmental risk factors and their influence on (ncRNAs) in connection to disease. We focus on well-studied miRNAs and analyze the novel roles of long-non-coding-RNAs (lncRNAs). We discuss commonly regulated lncRNAs after exposure to different stressors, such as UV, heavy metals and pesticides among others, and the potential role of these lncRNA as exposure biomarkers, epigenetic regulators and potential therapeutic targets to diminish the deleterious secondary response to environmental agents. |
url |
http://www.sciencedirect.com/science/article/pii/S2213231720302482 |
work_keys_str_mv |
AT veronicamiguel roleofnoncodingrnasinresponsetoenvironmentalstressorsandconsequencesonhumanhealth AT santiagolamas roleofnoncodingrnasinresponsetoenvironmentalstressorsandconsequencesonhumanhealth AT cristinaespinosadiez roleofnoncodingrnasinresponsetoenvironmentalstressorsandconsequencesonhumanhealth |
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