Angioedema and Fatty Acids

Angioedema and Fatty Acids

Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioede...

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Main Authors: Akane Wada, Yu Sawada, Hitomi Sugino, Motonobu Nakamura
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
angioedema
fatty acids
hereditary angioedema
Online Access:https://www.mdpi.com/1422-0067/22/16/9000
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spelling doaj-b71dc7d1dd1848bdaa2b756a47a8dcd52021-08-26T13:53:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-01229000900010.3390/ijms22169000Angioedema and Fatty AcidsAkane Wada0Yu Sawada1Hitomi Sugino2Motonobu Nakamura3Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, JapanDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, JapanDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, JapanDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, JapanAngioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid’s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.https://www.mdpi.com/1422-0067/22/16/9000angioedemafatty acidshereditary angioedema
collection DOAJ
language English
format Article
sources DOAJ
author Akane Wada
Yu Sawada
Hitomi Sugino
Motonobu Nakamura
spellingShingle Akane Wada
Yu Sawada
Hitomi Sugino
Motonobu Nakamura
Angioedema and Fatty Acids
International Journal of Molecular Sciences
angioedema
fatty acids
hereditary angioedema
author_facet Akane Wada
Yu Sawada
Hitomi Sugino
Motonobu Nakamura
author_sort Akane Wada
title Angioedema and Fatty Acids
title_short Angioedema and Fatty Acids
title_full Angioedema and Fatty Acids
title_fullStr Angioedema and Fatty Acids
title_full_unstemmed Angioedema and Fatty Acids
title_sort angioedema and fatty acids
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-08-01
description Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid’s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.
topic angioedema
fatty acids
hereditary angioedema
url https://www.mdpi.com/1422-0067/22/16/9000
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AT yusawada angioedemaandfattyacids
AT hitomisugino angioedemaandfattyacids
AT motonobunakamura angioedemaandfattyacids
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