Effects of KP-496, a Novel Dual Antagonist for Leukotriene D4 and Thromboxane A2 Receptors, on Contractions Induced by Various Agonists in the Guinea Pig Trachea
Background: A dry powder inhaler of KP-496 is currently in clinical development in Japan as an antiasthmatic agent. The aim of this study was to evaluate the in vitro pharmacological profile of KP-496. Methods: The antagonistic activities of KP-496 for leukotriene (Lt) D4 and thromboxane (TX) A2 rec...
Main Authors: | Masakazu Ishimura, Sayuri Kataoka, Masahiro Suda, Takashi Maeda, Yoshiyuki Hiyama |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2006-01-01
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Series: | Allergology International |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015309965 |
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