Cytoprotective Effect of Heat Shock Protein 27 Against Lipopolysaccharide-Induced Apoptosis of Renal Epithelial HK-2 Cells

Cytoprotective Effect of Heat Shock Protein 27 Against Lipopolysaccharide-Induced Apoptosis of Renal Epithelial HK-2 Cells

Background: In response to various stimuli, heat shock protein 27 (Hsp27) functions as an anti-apoptotic or/and anti-inflammatory factor which confers a survival advantage to cells. This study was aimed to explore whether Hsp27 also has a cytoprotective role in human renal tubular epithelial cells,...

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Bibliographic Details
Main Authors: Chunmei Li, Jiang Wu, Yuan Li, Guangqun Xing
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Heat shock protein 27 (Hsp27)
Lipopolysaccharide (LPS)
HK-2 cells
Septic acute kidney injury (septic AKI)
Bcl-2
NF-κB
JNK pathways
Online Access:http://www.karger.com/Article/FullText/475636

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