Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
IntroductionOur goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR).MethodsSerum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA...
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Frontiers Media S.A.
2020-10-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01917/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisa Cordero Elisa Cordero Angel Bulnes-Ramos Manuela Aguilar-Guisado Francisca González Escribano Israel Olivas Julián Torre-Cisneros Joan Gavaldá Teresa Aydillo Asunción Moreno Miguel Montejo María Carmen Fariñas Jordi Carratalá Patricia Muñoz Patricia Muñoz Patricia Muñoz Patricia Muñoz Marino Blanes Jesús Fortún Alejandro Suárez-Benjumea Francisco López-Medrano Francisco López-Medrano Francisco López-Medrano Cristina Roca Rosario Lara Pilar Pérez-Romero |
spellingShingle |
Elisa Cordero Elisa Cordero Angel Bulnes-Ramos Manuela Aguilar-Guisado Francisca González Escribano Israel Olivas Julián Torre-Cisneros Joan Gavaldá Teresa Aydillo Asunción Moreno Miguel Montejo María Carmen Fariñas Jordi Carratalá Patricia Muñoz Patricia Muñoz Patricia Muñoz Patricia Muñoz Marino Blanes Jesús Fortún Alejandro Suárez-Benjumea Francisco López-Medrano Francisco López-Medrano Francisco López-Medrano Cristina Roca Rosario Lara Pilar Pérez-Romero Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients Frontiers in Immunology cytomegalovirus alloreactivity donor specific antibodies anti-human leukocyte antigen organ rejection |
author_facet |
Elisa Cordero Elisa Cordero Angel Bulnes-Ramos Manuela Aguilar-Guisado Francisca González Escribano Israel Olivas Julián Torre-Cisneros Joan Gavaldá Teresa Aydillo Asunción Moreno Miguel Montejo María Carmen Fariñas Jordi Carratalá Patricia Muñoz Patricia Muñoz Patricia Muñoz Patricia Muñoz Marino Blanes Jesús Fortún Alejandro Suárez-Benjumea Francisco López-Medrano Francisco López-Medrano Francisco López-Medrano Cristina Roca Rosario Lara Pilar Pérez-Romero |
author_sort |
Elisa Cordero |
title |
Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients |
title_short |
Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients |
title_full |
Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients |
title_fullStr |
Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients |
title_full_unstemmed |
Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients |
title_sort |
effect of influenza vaccination inducing antibody mediated rejection in solid organ transplant recipients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-10-01 |
description |
IntroductionOur goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR).MethodsSerum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRATM Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch.ResultsWe studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%; P = 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developed de novo anti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA.ConclusionOur results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR. |
topic |
cytomegalovirus alloreactivity donor specific antibodies anti-human leukocyte antigen organ rejection |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01917/full |
work_keys_str_mv |
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doaj-b737a1dcc2e14d019260438be4f3574d2020-11-25T03:36:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.01917540242Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant RecipientsElisa Cordero0Elisa Cordero1Angel Bulnes-Ramos2Manuela Aguilar-Guisado3Francisca González Escribano4Israel Olivas5Julián Torre-Cisneros6Joan Gavaldá7Teresa Aydillo8Asunción Moreno9Miguel Montejo10María Carmen Fariñas11Jordi Carratalá12Patricia Muñoz13Patricia Muñoz14Patricia Muñoz15Patricia Muñoz16Marino Blanes17Jesús Fortún18Alejandro Suárez-Benjumea19Francisco López-Medrano20Francisco López-Medrano21Francisco López-Medrano22Cristina Roca23Rosario Lara24Pilar Pérez-Romero25Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainDepartment of Medicine, University of Seville, Seville, SpainInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainServicio de Inmunología, Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainServicio de Inmunología, Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainReina Sofia University Hospital, Maimonides Institute for Biomedical Research (IMIBIC), University of Córdoba (UCO), Córdoba, SpainVall d’Hebron University Hospital, VHIR, Barcelona, SpainInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainUniversity Hospital Clinic, Barcelona, SpainCruces University Hospital, Bilbao, SpainUniversity Hospital Marqués de Valdecilla, Santander, SpainBelltvitge University Hospital, IDIBELL, University of Barcelona, Barcelona, Spain0Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain1Instituto de Investigaciónn Biomédica Gregorio Marañón, Madrid, Spain2Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain3CIBERES (CB06/06/0058), Madrid, Spain4University Hospital La Fe, Valencia, Spain5University Hospital Ramón y Cajal, Madrid, Spain6University Hospital Virgen Macarena, Seville, Spain7Unit of Infectious Diseases, University Hospital 12 de Octubre, Madrid, Spain8Instituto de Investigación Biomédica imas12, Madrid, Spain9Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Madrid, SpainInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, SpainReina Sofia University Hospital, Maimonides Institute for Biomedical Research (IMIBIC), University of Córdoba (UCO), Córdoba, Spain0National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, SpainIntroductionOur goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR).MethodsSerum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRATM Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch.ResultsWe studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%; P = 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developed de novo anti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA.ConclusionOur results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.https://www.frontiersin.org/article/10.3389/fimmu.2020.01917/fullcytomegalovirusalloreactivitydonor specific antibodiesanti-human leukocyte antigenorgan rejection |