Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion
Abstract Background The aim of this study was to evaluate the correlation between changes in the macular capillary network and macular edema (ME) recurrence with branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography angiography (SS-OCTA). Methods We reviewed the data f...
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doaj-b745119e8f0e4115b2c1b8cb71628e2b2020-11-25T03:43:32ZengBMCBMC Ophthalmology1471-24152020-08-0120111110.1186/s12886-020-01611-wCorrelation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusionJi Hye Jang0Yu Cheol Kim1Jae Pil Shin2Department of Ophthalmology, Keimyung Universtiy School of MedicineDepartment of Ophthalmology, Keimyung Universtiy School of MedicineDepartment of Ophthalmology, Kyungpook National University School of MedicineAbstract Background The aim of this study was to evaluate the correlation between changes in the macular capillary network and macular edema (ME) recurrence with branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography angiography (SS-OCTA). Methods We reviewed the data for 43 patients with treatment-naïve ME associated with BRVO. Patients who received intravitreal bevacizumab injection were divided into two groups based on ME recurrence at 6 months after edema resolution. The perifoveal capillary morphology and the macular capillary vessel density (VD) were retrospectively analyzed using en face SS-OCTA after ME resolution. Results The perifoveal capillary ring loss in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was more common in the ME recurrence group (n = 22) than in the no ME recurrence group (p = 0.047 and p = 0.002). Relative to the findings in the no ME recurrence groups, the destruction of the perifoveal capillary ring was more severe in the DCP (30.0° vs 87.3°, p = 0.001) than in the SCP (17.3° vs 69.5°, p = 0.006) in the ME recurrence group. The hemi-VD disparity between the affected and the unaffected areas in the SCP and DCP showed significant differences (p = 0.031 and p = 0.017), while macular VD showed no differences between the groups. Conclusions Destruction of the perifoveal capillary ring and hemi-VD disparity could be related to ME recurrence in BRVO. Therefore, these factors may be helpful in predicting ME recurrence.http://link.springer.com/article/10.1186/s12886-020-01611-wBranch retinal vein occlusionMacular capillary networkMacular edemaOptical coherent tomography angiographyVessel density |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Hye Jang Yu Cheol Kim Jae Pil Shin |
spellingShingle |
Ji Hye Jang Yu Cheol Kim Jae Pil Shin Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion BMC Ophthalmology Branch retinal vein occlusion Macular capillary network Macular edema Optical coherent tomography angiography Vessel density |
author_facet |
Ji Hye Jang Yu Cheol Kim Jae Pil Shin |
author_sort |
Ji Hye Jang |
title |
Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion |
title_short |
Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion |
title_full |
Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion |
title_fullStr |
Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion |
title_full_unstemmed |
Correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion |
title_sort |
correlation between macular edema recurrence and macular capillary network destruction in branch retinal vein occlusion |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2020-08-01 |
description |
Abstract Background The aim of this study was to evaluate the correlation between changes in the macular capillary network and macular edema (ME) recurrence with branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography angiography (SS-OCTA). Methods We reviewed the data for 43 patients with treatment-naïve ME associated with BRVO. Patients who received intravitreal bevacizumab injection were divided into two groups based on ME recurrence at 6 months after edema resolution. The perifoveal capillary morphology and the macular capillary vessel density (VD) were retrospectively analyzed using en face SS-OCTA after ME resolution. Results The perifoveal capillary ring loss in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was more common in the ME recurrence group (n = 22) than in the no ME recurrence group (p = 0.047 and p = 0.002). Relative to the findings in the no ME recurrence groups, the destruction of the perifoveal capillary ring was more severe in the DCP (30.0° vs 87.3°, p = 0.001) than in the SCP (17.3° vs 69.5°, p = 0.006) in the ME recurrence group. The hemi-VD disparity between the affected and the unaffected areas in the SCP and DCP showed significant differences (p = 0.031 and p = 0.017), while macular VD showed no differences between the groups. Conclusions Destruction of the perifoveal capillary ring and hemi-VD disparity could be related to ME recurrence in BRVO. Therefore, these factors may be helpful in predicting ME recurrence. |
topic |
Branch retinal vein occlusion Macular capillary network Macular edema Optical coherent tomography angiography Vessel density |
url |
http://link.springer.com/article/10.1186/s12886-020-01611-w |
work_keys_str_mv |
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