Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas

Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas

Pheochromocytoma/paragangliomas (Pheo/PGL) are rare endocrine cancers with strong genetic background. Mutations in the <i>SDHB</i> subunit of succinate dehydrogenase (SDH) predispose patients to malignant disease with limited therapeutic options and poor prognosis. Using a host of cellul...

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Bibliographic Details
Main Authors: Balazs Sarkadi, Katalin Meszaros, Ildiko Krencz, Letizia Canu, Lilla Krokker, Sara Zakarias, Gabor Barna, Anna Sebestyen, Judit Papay, Zoltan Hujber, Henriett Butz, Otto Darvasi, Peter Igaz, Judit Doczi, Michaela Luconi, Christos Chinopoulos, Attila Patocs
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
succinate
sdh
sdhb
pheochromocytoma
paraganglioma
gls-1
Online Access:https://www.mdpi.com/2072-6694/12/3/599

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