A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl– for H+). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models harmonize with many experimental findings, gaps and...

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Bibliographic Details
Main Authors: Tanmay S Chavan, Ricky C Cheng, Tao Jiang, Irimpan I Mathews, Richard A Stein, Antoine Koehl, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
antiporter
membrane exchanger
crystallography
MD simulations
DEER spectroscopy
chloride
Online Access:https://elifesciences.org/articles/53479

Internet

https://elifesciences.org/articles/53479

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