Fertility Potential in Adult Hypospadias
Introduction: Hypospadias is a congenital anomaly of the urogenital tract characterized by abnormal location of the external urethral meatus over ventral aspect of penis. The ideal time to correct primary hypospadias is when aged 6-12 months. However, in some developing countries, such as ours,...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-08-01
|
Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/8276/21307_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
id |
doaj-b74c71495f2647cebc19595f741be21c |
---|---|
record_format |
Article |
spelling |
doaj-b74c71495f2647cebc19595f741be21c2020-11-25T03:19:54ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-08-01108PC01PC0510.7860/JCDR/2016/21307.8276Fertility Potential in Adult HypospadiasSANJAY KUMAR0VINAY TOMAR1SHER SINGH YADAV2SHIVAM PRIYADARSHI3NACHIKET VYAS4NEERAJ AGARWAL5Senior Resident, Department of Urology, S.M.S Medical College, Jaipur, Rajasthan, India.Head of Department, Department of Urology, S.M.S Medical College, Jaipur, Rajasthan, India.Unit Chief, Department of Urology, S.M.S Medical College, Jaipur, Rajasthan, India.Unit Chief, Department of Urology, S.M.S Medical College, Jaipur, Rajasthan, India.Additional Professor, Department of Urology, S.M.S Medical College, Jaipur, Rajasthan, India.Associate Professor, Department of Urology, S.M.S Medical College, Jaipur, Rajasthan, India.Introduction: Hypospadias is a congenital anomaly of the urogenital tract characterized by abnormal location of the external urethral meatus over ventral aspect of penis. The ideal time to correct primary hypospadias is when aged 6-12 months. However, in some developing countries, such as ours, this anomaly may be left untreated until adulthood. There are multiple risk factors responsible for development of this anomaly, out of which paternal sub fertility is one of them. As the child grows into adulthood, fertility status becomes an important issue, frequently raised by patients. Aim: To evaluate the fertility potential of adult hypospadiac patients and to rule out the effect of age of surgical correction over fertility potential. Materials and Methods: Seventy three adult patients of hypospadias were prospectively evaluated, out of which 43 were operated during adulthood. All patients underwent measurement of penile length and circumference in both flaccid and erect positions along with testicular volume, serum LH, FSH and testosterone and semen analysis. A set of questionnaire was given to all the patients which included assessment of erectile function (IIEF-5), ejaculatory function, strength of libido and level of satisfaction after sexual intercourse. Results were compared with an age matched control group of 70 healthy person. Results: Out of 73 patients with a mean age of 23.73 years, 14(19.17%) had proximal and rest 59(80.82%) had distal type of hypospadias. Mean penile length in both type of hypospadiac patients under both flaccid and erect conditions (7.92±1.33 and 9.62±1.31cm) were significantly shorter than those of control (10.78±0.94 and 13.15±1.15 cm) (p<0.001). In spite of short penile length, the level of satisfaction of all patients and their partner after penetrating intercourse were comparable to control (p>0.05). The strength of libido (p>0.05) was comparable with control in both type of hypospadiac patients; however IIEF-5 scores was poor in the proximal type of hypospadias. Semen volume (ml), sperm concentration (mill/ml), active sperm motility (%), and normal sperm morphology were comparable between distal hypospadiac group and control (p>0.05), however these parameters were poor in proximal type. The serum FSH and LH levels were significantly higher and serum testosterone level was significantly lower in hypospadiac patients than control (p <0.001). However, no difference in testicular size was found. The patients who were operated during childhood had shorter penile length compared to patients operated during adulthood. Conclusion: Fertility potential parameters in distal type of hypospadias were comparable with control. However the proximal type had poor erectile function and semen quality. Patients operated in either childhood or in adulthood, there was no significant difference in fertility potential.https://jcdr.net/articles/PDF/8276/21307_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdfcongenital anomalyerectile dysfunctionsemen analysisurogenital tract |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
SANJAY KUMAR VINAY TOMAR SHER SINGH YADAV SHIVAM PRIYADARSHI NACHIKET VYAS NEERAJ AGARWAL |
spellingShingle |
SANJAY KUMAR VINAY TOMAR SHER SINGH YADAV SHIVAM PRIYADARSHI NACHIKET VYAS NEERAJ AGARWAL Fertility Potential in Adult Hypospadias Journal of Clinical and Diagnostic Research congenital anomaly erectile dysfunction semen analysis urogenital tract |
author_facet |
SANJAY KUMAR VINAY TOMAR SHER SINGH YADAV SHIVAM PRIYADARSHI NACHIKET VYAS NEERAJ AGARWAL |
author_sort |
SANJAY KUMAR |
title |
Fertility Potential in Adult Hypospadias |
title_short |
Fertility Potential in Adult Hypospadias |
title_full |
Fertility Potential in Adult Hypospadias |
title_fullStr |
Fertility Potential in Adult Hypospadias |
title_full_unstemmed |
Fertility Potential in Adult Hypospadias |
title_sort |
fertility potential in adult hypospadias |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-08-01 |
description |
Introduction: Hypospadias is a congenital anomaly of the
urogenital tract characterized by abnormal location of the
external urethral meatus over ventral aspect of penis. The ideal
time to correct primary hypospadias is when aged 6-12 months.
However, in some developing countries, such as ours, this
anomaly may be left untreated until adulthood. There are multiple
risk factors responsible for development of this anomaly, out of
which paternal sub fertility is one of them. As the child grows
into adulthood, fertility status becomes an important issue,
frequently raised by patients.
Aim: To evaluate the fertility potential of adult hypospadiac
patients and to rule out the effect of age of surgical correction
over fertility potential.
Materials and Methods: Seventy three adult patients of
hypospadias were prospectively evaluated, out of which
43 were operated during adulthood. All patients underwent
measurement of penile length and circumference in both flaccid
and erect positions along with testicular volume, serum LH, FSH
and testosterone and semen analysis. A set of questionnaire
was given to all the patients which included assessment of
erectile function (IIEF-5), ejaculatory function, strength of libido
and level of satisfaction after sexual intercourse. Results were
compared with an age matched control group of 70 healthy
person.
Results: Out of 73 patients with a mean age of 23.73 years,
14(19.17%) had proximal and rest 59(80.82%) had distal type of
hypospadias. Mean penile length in both type of hypospadiac
patients under both flaccid and erect conditions (7.92±1.33 and
9.62±1.31cm) were significantly shorter than those of control
(10.78±0.94 and 13.15±1.15 cm) (p<0.001). In spite of short
penile length, the level of satisfaction of all patients and their
partner after penetrating intercourse were comparable to control
(p>0.05). The strength of libido (p>0.05) was comparable with
control in both type of hypospadiac patients; however IIEF-5
scores was poor in the proximal type of hypospadias. Semen
volume (ml), sperm concentration (mill/ml), active sperm motility
(%), and normal sperm morphology were comparable between
distal hypospadiac group and control (p>0.05), however these
parameters were poor in proximal type. The serum FSH and
LH levels were significantly higher and serum testosterone level
was significantly lower in hypospadiac patients than control (p
<0.001). However, no difference in testicular size was found.
The patients who were operated during childhood had shorter
penile length compared to patients operated during adulthood.
Conclusion: Fertility potential parameters in distal type of
hypospadias were comparable with control. However the
proximal type had poor erectile function and semen quality.
Patients operated in either childhood or in adulthood, there was
no significant difference in fertility potential. |
topic |
congenital anomaly erectile dysfunction semen analysis urogenital tract |
url |
https://jcdr.net/articles/PDF/8276/21307_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
work_keys_str_mv |
AT sanjaykumar fertilitypotentialinadulthypospadias AT vinaytomar fertilitypotentialinadulthypospadias AT shersinghyadav fertilitypotentialinadulthypospadias AT shivampriyadarshi fertilitypotentialinadulthypospadias AT nachiketvyas fertilitypotentialinadulthypospadias AT neerajagarwal fertilitypotentialinadulthypospadias |
_version_ |
1724620311962320896 |