Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies
Neuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia. However, the precise mechanisms remain obscure. To better understand neuroinflammation in PD, we focused on glial activation in α-synuclein (...
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doaj-b74e8b59a4bf4859935cede3a778cc9c2020-11-24T23:54:11ZengHindawi LimitedParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/271732271732Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-SynucleinopathiesKazunari Sekiyama0Shuei Sugama1Masayo Fujita2Akio Sekigawa3Yoshiki Takamatsu4Masaaki Waragai5Takato Takenouchi6Makoto Hashimoto7Division of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, JapanDepartment of Physiology, Nippon Medical School, Tokyo 113-8602, JapanDivision of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, JapanDivision of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, JapanDivision of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, JapanDivision of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, JapanDivision of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, JapanDivision of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-0057, JapanNeuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia. However, the precise mechanisms remain obscure. To better understand neuroinflammation in PD, we focused on glial activation in α-synuclein (αS) transgenic and related model mice. In the majority of αS transgenic mice, astrogliosis was observed concomitantly with accumulation of αS during the early stage of neurodegeneration. However, microglia were not extensively activated unless the mice were treated with lipopolysaccharides or through further genetic modification of other molecules, including familial PD risk factors. Thus, the results in αS transgenic mice and related model mice are consistent with the idea that neuroinflammation in PD is a double-edged sword that is protective in the early stage of neurodegeneration but becomes detrimental with disease progression.http://dx.doi.org/10.1155/2012/271732 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazunari Sekiyama Shuei Sugama Masayo Fujita Akio Sekigawa Yoshiki Takamatsu Masaaki Waragai Takato Takenouchi Makoto Hashimoto |
spellingShingle |
Kazunari Sekiyama Shuei Sugama Masayo Fujita Akio Sekigawa Yoshiki Takamatsu Masaaki Waragai Takato Takenouchi Makoto Hashimoto Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies Parkinson's Disease |
author_facet |
Kazunari Sekiyama Shuei Sugama Masayo Fujita Akio Sekigawa Yoshiki Takamatsu Masaaki Waragai Takato Takenouchi Makoto Hashimoto |
author_sort |
Kazunari Sekiyama |
title |
Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies |
title_short |
Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies |
title_full |
Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies |
title_fullStr |
Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies |
title_full_unstemmed |
Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies |
title_sort |
neuroinflammation in parkinson's disease and related disorders: a lesson from genetically manipulated mouse models of α-synucleinopathies |
publisher |
Hindawi Limited |
series |
Parkinson's Disease |
issn |
2090-8083 2042-0080 |
publishDate |
2012-01-01 |
description |
Neuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia. However, the precise mechanisms remain obscure. To better understand neuroinflammation in PD, we focused on glial activation in α-synuclein (αS) transgenic and related model mice. In the majority of αS transgenic mice, astrogliosis was observed concomitantly with accumulation of αS during the early stage of neurodegeneration. However, microglia were not extensively activated unless the mice were treated with lipopolysaccharides or through further genetic modification of other molecules, including familial PD risk factors. Thus, the results in αS transgenic mice and related model mice are consistent with the idea that neuroinflammation in PD is a double-edged sword that is protective in the early stage of neurodegeneration but becomes detrimental with disease progression. |
url |
http://dx.doi.org/10.1155/2012/271732 |
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