Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in academia and industry. In particular, animal toxi...
Main Authors: | Denis B. Tikhonov, Boris S. Zhorov |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-08-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.00880/full |
Similar Items
-
Enhancement of closed-state inactivation by neutralization of S4 arginines in domain IV of a sodium channel
by: Tzur ePaldi
Published: (2012-07-01) -
Systematic Study of Binding of μ-Conotoxins to the Sodium Channel NaV1.4
by: Somayeh Mahdavi, et al.
Published: (2014-12-01) -
Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs
by: Denis B. Tikhonov, et al.
Published: (2021-07-01) -
The application of molecular techniques to investigate the production of sodium channel blocking toxins by heterotrophic marine bacteria
by: Hosie, Arthur Hugh Frank
Published: (1998) -
Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations
by: Fangling Chen, et al.
Published: (2018-05-01)